ࡱ> q` R bjbjqPqP2::J"""""""4 N.v.......$hW"..""..{"."."".j e^  l0;";;"$.^L\b... ...dF DF 6"""""" The development of the research of peroxidases in mechanism and application  HYPERLINK "mailto:xiabl@ustc.edu.cn" Xia Bingle, Peng Dungeng, Liu Qingliang (Department of Chemistry, University of Science and Technology of China, Hefei 230026) Abstract On the basis of reading a large number of articles, we reviewed the development of the research in mechanism and application of several peroxidases. We made a compare the commonness and individuality of the peroxidases in the mechanism and the application. The insufficiency in the researches was pointed and a prospect of the researches, which we thought were necessary in these fields in the following years, was made in this review. Keywords peroxidase, reaction mechanism, application, development Ǐ'lSirvvS^:gtT^(uvxvzۏU\  HYPERLINK "mailto:xiabl@ustc.edu.cn" YpPN m_fe RnN (-NVyf[b/g'Yf[Sf[|,T,230026) 2002t^9g16e6e?zV[pINpN@\yxWёDR0 Xd (W,ge-NbN\TyegnvǏ'lSirvvSvS^:gtv^=\ϑ~T[Nv~gNS^(u\ON~0(WN~S^:gtT^(uvePU\:yN[Nv*N'` v^;`~N[NvqQ'`cQNvMRxvz]\Ov Nv^[NTǏ'lSirv(WُNWvxvz\ONU\g0 sQ.͋ Ǐ'lSirv S^:gt ^(u ۏU\ Ǐ'lSirv(Peroxidase,EC1.11)/f^lX[(WNuirSO-NvN{|v,'YR+T g@~ } /fNy~Tˆ}v0[SNPSH2O2bvsQ g:gǏ'lSTirN g:g0e:gSTirv'lSS^[1-5]0NN[ُ{|vvRy~S0S^:gt0~gT^(u\OǏv^vxvz0 vMR Ǐ'lSirv(Wvvg^0MQuKm[b/gToirʋeb/g N^(u:N^l0SY^(u(Wuir OahV oirv9eۏ Sf[ՋBRvuN STirvM sXvKm (WPgeyf[W_N g^(u kYuNe2uZPnBRvhme[؏(uN|bRvvf[Km[ $\vQ(uN|?\uvʋe0'Yybv iirǏ'lSirvv T]v [NnfMv'`(T(WYupOevkrRgelO_Ǐ'lSirv\O:NNyO)Rvvhir (WWVf[0utf[Tutf[xvz-NS%cN͑\O(u0Ǐ'lSirv؏8^8^^(uN g8OU\ˆ}vSNvY|c02TTYNxv'lS0bu'`S~ހuSv0 Nb~TǏ'lSirvv~g N[NvS^:gtT[N(W[Eu;m-Nv^(u$Neb ~VQY(WُN]\O NvۏU\0 1. :gt Ǐ'lSirvvPS:gtNv/fNNxvzvN*Npp PSsQlvSV/fWN[N(W(g(S0~ހRS0~ހXOS O0IAAeHN"0bu'`Sbk'`-NSnbogvQ͑v\O(u0 Nb~TǏ'lSirvvv~g[vQPSS^:gtvxvzۏU\\ONN~0 1.1 HRPvPS:gt HRP/fNNe)R(uTxvzvǏ'lSirv0v[NvQNǏ'lSirv [[vxvzf:N|~T~ N N1\[(WS^T^(u-Nv\O(u:gt\ON{USN~0HRPvXM\~g]N1997t^Q0~g>f:y [Teg TN[e,{ N[e vuǏ'lSirv0'YǏ'lSirv gN*NqQ Tp sS(W@~ }vSYpocket R:NяzT܏zv$N*NR ˆ}vbS-NSW@w$N*NyP[0 AndersonI{N [1](uRRx:WHe^xvzN HRPv-NSTir ,:N HRP_sS^vzSO~gS(uV1h:y .RGW*mI{(u9hǏ'lSirvPS(g }NZ(WSv_sNm|~-NۏLNqQZS^ [>f:y9eSQ萄v"l.~g[2]0 [NS^-NSOvX[(WR^nu yy[KbkfN[vX[(W,FO-NSO0R^/fUOy~g tSO~~0Dunford,HaesunI{N:N(W-N'`Tx'`nm-NSTir I vb_bǏ zY N@b:y: H2P!HP!P+H2O2!HRP-I N Tv/f NN(Wcek N gN,T:N(Wb_bHRP-IKNMR؏ gN*N gNyS~gvSTir0vX[(W v^cQNǏ'lSirvvlSek ~Q[SSe.s[3]0  INCLUDEPICTURE "http://china.chemistrymag.org/cji/2003/images/05100102.gif" \* MERGEFORMATINET  V1 9hǏ'lSirvvPS_s Fig.1 Catalytic cycles of horseradish peroxidase 1.1.2 HRPuir5ug Nvuir5uPS؏S:gt Ǐ'lSirvOp5ug(W H2O20Z{|0a|I{ir(vKm[-N g@w_͑v\O(u ,@bNяt^eg_0RN:N^lvxvzTSU\[4]0 HRP(W5ughb N'lSb_b-NSTir I T II, H2O2vcN5ug N_0R5uP[ ؏S (vc5uP[ly ),bN'lS؏SZNir N_0R5uP[ ؏S (c5uP[ly ),ُ$Ny5uP[lye__NS TeSu [5],$Nye__0Rv؏S5uAmTǏ'lSirvSm^ gsQ0 N ,S_Ǐ'lSirSm^_ؚe ,HRPSb_bNy N;mlvb__STir ('lS`:N +6).hKmg{USv HRPOp5ug ,/f(WWSO5ughb8TD NNB\ HRPRP[gb0HRP5ug(WPS_sǏ z-NSuvS^Y N: HRP(Fe3 )+H2O2 !Compound-I (1) Compound-I +AH2 !Compound-II +AH (2) Compound-II +AH2 ! HRP(Fe3+) +AH +H2O (3) S_bdk5ug>eeQ_Km7hT-N ,v^Oc5ug5uMONON600m V(SCE)e ,HRP'lSS^v-NSTirN5ug N_0R5uP[ ؏S ,؏S5uAmNH2O2vSm^bkO , TeOnm-N_{ gH2O2X[(W0(WُyagN N HRPN5ugKNv5uP[/fvclyv[4]0 HRPS^-NSOSTirITSTirIIf8^v؏Se_ ,/fN^ir N_0R5uP[0HRPPSS^b_bv'lSNirSQN^ir (5uP[OSO )v'`(0{|SZ{|I{5uP[OSO ,(W'lSTb_b1uW AH; gv^irYmQ0lTxvII(hexacyanoferrate II)1YSN*N5uP[bxyP[1YS$N*N5uP[T ,v^ Nb_b1uW05uP[OSO'lSTb_bvNir (1uW AH ),SQSuY NS^[5]:  INCLUDEPICTURE "http://china.chemistrymag.org/cji/2003/images/05100103.gif" \* MERGEFORMATINET  vQ-NFe3+:N HRPvVP[ ,AH2:N5uP[OSO ,8^:NbZ{|STir ,AH:N'lSTNuv1uW0S^ -N HRP H2O2bNORP[ϑv g:gǏ'lSir'lS ,1YS$N*N5uP[ub-NSTirI ('lS`:N +5N ),-NSO1u+T'l(Fe4+=O)TN*N_SIU3yP[~b ;(WTvS^-N ,STir I N,{N*N5uP[OSOAH2 N_0RN*N5uP[ ,؏S:N-NSTirII ('lS`:N +4N );(WgTNekS^-N ,-NSTirIIN,{N*N5uP[OSO AH2 NS_0RN*N5uP[ ,dk HRP؏S:NRYr`0Annika LindgrenI{NbSNǏ'lS"l(WHRPbTAPOpv5ug Nvvc؏SǏ z v^Ss(Wُ*Nuir5u؏SǏ z-NHRPvPS'`fsO[4]0 1.2 TsNRirǏ'lSirv(Mammalian peroxidase) N iirǏ'lSirvvwnvf:y+T g@~ }v iirǏ'lSirvSN(Wl gYuvǏ'lS"lirv`Q N[bPSS^0 (W:\H2O2v`Q N1u iirǏ'lSirvPSO2NIAAvS^/fN*Ng͑vutS^0IAA(WǏ'lSir1uWPS NvMS^eN1955t^1\_YNNxvz01uN gY~ YBgvkWS^ [vQS^:gt,av^ N~N0g:NnfMv‰p/f1 ^6 E EI EII :NSvSv^v YTir0IAAOOH egnNIAA IAAOH/fvQ[^v IAA+O2! IAA.+ 1 IAA.+ O2! IAAO2. 2 IAAO2. +IAA +? ! IAAOOH+IAA. 3 E+ IAAOOH! EI +IAAOH 4 EI +IAA! EII +IAA. 5 EII+ IAA! E +IAA. 6 Irina G.Gazarian]~(We.s[7]-NN (W3z[r` N TOPPSIAAOHf>fS0RǏ'lS"lvvq_T ]wHRPPSS^NǏ'lS"lvesQ0SY(W[TOP/HRPvGANSIENTRRf[xvz-NSTirIl g‰[0R. ,{Ny[HRPcQv:gt/f^z(WSTirIIIvSNW@x Nv E+ IAA! E2+ +IAA.+ 7 E2++ O2! EIII 8 EIII+ IAA! E2++ IA +CO2+ H2O 9 EIII+ 2IAA! EII +2IAA. 10 EII+ IAA! E-IAA.+ H2O 11 E-IAA. +O2! EII+In-CH2O +CO2 12 e.s[7]:N(We'l`Q NvTIAA S^-NI{_7 /f NX[(Wv,V:Nl gYvnchfُykWb_bvS'`0V Nuُy;NvkWvǏ z؏/f NnZi0 Inna G. GazaryanI{:N;NvkWvubS_ g_ϑё^\yP[X[(We IAAMe TeNukW 1\/f1uv,gPSb_bv[8]: E+ O2+ IAA ! [IAA-E-O2] 13 [IAA-E-O2] ! E +IAA.+ +O2.- 14 1.4 LiP(Lignin peroxidase) LiP/fNyegnNw̃vǏ'lSirv [(W iirv(g(SǏ z-NS%cNsQ.v\O(u0[[vxvzkY vIQ;NƖ-N(WvQ~g uS:gI{eb0 (g( }Ǐ'lSirvLiP 1u343*N(lWxkW 370*N4lRP[ @~ } 4*N|T$N*NyP[~b0(g( }Ǐ'lSirv>f:yNxQWvǏ'lSirvvzzbS`Q N@~ } gN*NT(WvQNǏ'lSirv-NN7hv\핯sXclose environment 0] gbS(WTrp171Y؏X[(W,{N*N^ir~TMOp ُT]bSvvQNvǏ'lSirvv~xQ@~ } N T0ItakuraTHenriksenR+R[~xQv@~ }(WvQNvǏ'lSirv-N@~ }/fT^irvN\O(uvMO vf6q\O:NuirؚZirv(g( }/felc0R@~ }v[6]0(WTrp171MOp NO(ueUcve_b_b v^[NTrp171 /fN*N g'lS؏S;m'`v(lWx SN܅v'lS0(Wdk!jWvW@x N N܅v'lSTSv(g(SvsQvTrp1710R@~ }vUS5uP[S]‰[0R0 (W_>ev_N@~ }vvSeSN~T\v^irRP[vMO gN*N\vSSN0R܏zvN@~ }SSNǏ'lS"lRP[ۏeQ 0 NSs(WLiP-Nv@~ }yP[Tяzv~(lxkW NvNSP[v.f>fk(W~ހr }CǏ'lSirvv0(WLiP-N1_vFe-N.HTsf_v5uP[ O N3z[Tvؚ'lS` SN}Y0WʑLiPkCcP gfؚv'lS؏SR0LiP gN*Ncяtb_vn^ N~:\^'Y~/f504040 v^@~ }RrR:N$NRя:SW8h܏:SW0@~ }[hQ ieQ0Rˆ}v-N v^SNǏ$N*Nr\vScя0US*NLiPRP[ g8*N;Nvae 8*N\e 3agwvSs^LabGr kN*N/fS1u$N*NkW~b0@~ }-N g$N*N gyP[~TMO N*N(W܏:SW N*N(Wя:SW0NSP[veT w $N*NMON;m'`MOpv~(lxkWKNT TeT7^8*N'lSP[MMO 'lSP[KNvݍy(W2.340R2.72[9]0 @~ }vzztzcavity /f1u40*NkW~b @~ } NvSP[TgcяvHis176v.lSP[~T .:N2.15,,{mQ*NT~TvMOp/fN*N4lRP[ [Ǐ"l.T܏zvHis47NSvQ[v$N*N4lRP[~T0(WNxoTArg430Ala1800Asn182NAsp183KN @~ }Ǐ"l.Tˆ}v~T0@~ }Tˆ}vKNOYuv"l./f(WArg43TAsn182KNb_bv [Nv^1_Np ݍ/f3.200EPRIQ1VTqQ/cbf1V>f:y@~ }vSP[;N:Nؚev NN[9]0 Haemmerli S.D.I{NfcQNYV3v(g( }Ǐ'lSirv(W'llX[(WePS'lS܅PS:gt:yaV0FO/fRimko ten HaveTNvT\O(Wxvz(g( }Ǐ'lSirv(W'llX[(WePS'lS܅vǏ z-NcQ_ NN:N(WS^-NoRNirvb_bv^ N/f1uN4l[VA1uW3yP[v\O(u@b bv :N/fHQۏLv/f'llNVA1uW3yP[v\O(u 6qTMb/f4lv ۏ;e 0  INCLUDEPICTURE "http://china.chemistrymag.org/cji/2003/images/05100105.gif" \* MERGEFORMATINET V3 (WVADvNS(g( }Ǐ'lSirvPSVA'lSǏ z-NoRNirb_bvS^:gtv:yaVVA܅;VAD ܅ [10] Fig.3 A schematic representation of the reaction mechanism involved in the formation of VAD and side products by the LiP catalyzed oxidation of VA INCLUDEPICTURE "http://china.chemistrymag.org/cji/2003/images/05100106.gif" \* MERGEFORMATINET  V4. 0Ǐ'lSirvvPS_sV Fig. 4 The catalytic cycle of manganese peroxidase (MnP)[11] 1.5 0Ǐ'lSirv(MnP,Manganese peroxidase) ] gbS Ny N TvMnP0Ǐ'lSirv]~_N~S vQ-NNy]~_0RvQ^R0Ǐ5ulRg MnPvRP[ϑ:N43Kda vQI{5up/f3.750ُyv/fNy+T5v|Wv|ˆ}v0 cvQRP[ϑ:N43Kda{ Ty(lWxkWvpev/f50Asp 15Thr 49Ser 37Glu 33Gly 36Ala 17Val 4Met 11Ile 17Leu 7Tyr 21Phe 6His 5Lys 11ArgT19ProCysTTrppev Nnx[ 0 Mnpv$N*N T]vǏSDS-PAGE5ulKm_:N44KDa (WNzS|WSǏ z-N MnP-IvRP[ϑM0RN42.7Kda >f:yN g3vNcv{|0MnP1vI{5up/f3.45 MnP2vI{5up/f3.35ǏIEFKm_ 0$NyLiPvRP[ϑ/f48Kda nzS|WSvR:N45.5Kda hf g5vNcv{|0S|WST$N*N T]vvI{5upR+R/f3.1T3.00Rg~g>f:yegnN B. adusta vǏ'lSirv(lWxkWv~b/f(MnP1, LiP2): Asx (49, 56), Thr (26, 41), Ser(30, 19), Glx (39, 39), Gly (37, 39), Ala (47, 60), Cys(6, 6), Val (24, 22), Met (6, 10), Ile (19, 21), Leu (27,30), Phe (28, 36), His (9, 9), Lys (8, 7), Arg (10, 11),Pro (35, 35) and Tyr (0, 0) (Trp ؏l g_0Rnx[) (W LiP b MnPv T]vKNl gSsNHN~_v:S+R[10]0 0Ǐ'lSirv/f@b gǏ'lSirv-NryrvN*N,[AQ[v؏S^irb:NMn2+ YTir0MnPvSTirI؏SN'lSN|RSTir,ONaR(gZT2,6-N2u'lWZ2,6-dimethoxyphenol , (Whitwam et al.,1997)FOkMn2+vHesNO,STirIIv؏SMn2+\O:N^ir.[vSvS^:gt/f Ferric enzyme+H2O2!Compound I+H2O (1) Compound I+RH!Compound II+R 2 CompoundII+RH!Ferric enzyme+R+H2O 3 Compound II+RH!Compound II--RH!Ferric enzyme+R+H2O4 Compound II+H2O2!Compound III (5) RH/f؏S^ir,R*/fUS5uP['lSTv؏S^ir[12]  INCLUDEPICTURE "http://china.chemistrymag.org/cji/2003/images/05100107.gif" \* MERGEFORMATINET V5 ARP-N@~ }sX Fig.5 Heme environment of ARP1.6 ARP(A.ramosus peroxidase)vPS:gt +T gN@~ }vǏ'lSirv g$N*NHiskWTN*NArgkW ُ/f(W@b gvǏ'lSirv-N/f NSv0؏ gvxvz~g>f:y(W_YvǏ'lSirv-NN*NHiskW(WяzT@~ }-NvSP[MMOޏc SN*NR/fTArgkWNw(W܏zTSP[MMO0vfSOf[xvzhf(WARP(the A. ramosus peoxidase)-NHis 184THis 56R+R[^NяzT܏zvHis, Arg 52[^N܏zvArg 0gяvxvzhf@~ }v,{mQ*NOS T\O(uMOp/f(lRP[pH:N7.5e (u 415 h:y Toru Nakayamaʑُ/f1uN(W~vfvePO(u(lRP[ bv YV5@b:y0 g~g>f:yARPvPSS^:gt/f cgqY NvekۏLv ARP[Fe(III)]+H2O2!compound I[Fe(IV) ]+H2O (1) Compound I[Fe(IV) ]+AH2!compound II[Fe(IV)]+AH (2) compound II[Fe(IV)]+AH2!ARP[Fe(III)]+AH +H2O (3) 2AH !A+AH2(bA2H2) (4)  INCLUDEPICTURE "http://china.chemistrymag.org/cji/2003/images/05100108.gif" \* MERGEFORMATINET  V6 FukuyamaTAbelskovI{NcKmvARPvPS:gt0ek1 4h:ySTirIvb_b 6 11h:ySTirITIIvOpǏ z ek5/f:NNޏc$NR _ۏv0|~h:yARPˆ}v s^bwb_h:y@~ }s^bZ~h:ySb"l.(WQv1_vN\O(u0Ǐ'lSirvvIQf[penchfSTirIS+TN*N&^ gck5uwv_SIUsvFec!O0 [14]. Fig.6 Proposed mechanism of ARP catalysis as depicted by Fukuyama 0Abelskov et al.. Steps KLMst~b r  Z \ b ͱ ’ ybMM5/hGIhGI>*B*CJKHOJQJ^Jo(ph)jhGIhGICJKHOJQJU^J-hGIhGI5CJ$H*KHOJQJ\^JaJ$1hGIhGI5CJKHOJPJQJ\^JaJo(hGIhGI5CJKH\ hGIhGICJKHOJQJ^J hGIhGI>*B*CJKHphhGIhGICJKHjhGIhGICJKHU&hGIhGI5CJKHOJQJ\^JhGIhGI5CJ$KH\aJ$L r`()2 ??xAzADBIkdd$$If0$ $634a $$1$Ifa$gdGI$dd1$[$\$a$gdGI b d j p r z | .JLxz|~rxƵơƵƌƵƵƵzzfP*hGIhGI5CJKHOJPJQJ\^J&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJH*KHOJQJ^J)hGIhGI5CJKHOJQJ\^Jo('hGIhGICJKHOJQJ^JaJo( hGIhGICJKHOJQJ^J#hGIhGICJKHOJQJ^Jo(#hGIhGICJH*KHOJQJ^J)jhGIhGICJKHOJQJU^Jx|h V\`b"(*.JT֭֭֭֙֙֙քsdXD&hGIhGI5CJKHOJQJ\^JhGIhGICJKHo(hGIhGI5CJKH\o( hGIhGICJKHOJQJ^J)jhGIhGICJKHOJQJU^J&hGIhGICJH*KHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo(-hGIhGI5CJKHOJPJQJ\^Jo(^d@FTX^`bd$(0z|ذذذذذذذ؛ hGIhGICJKHOJQJ^J)jhGIhGICJKHOJQJU^J&hGIhGICJH*KHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJKHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(/|~ vzF H !!!X!!!################$$$$$$$$$$$%6%8%ïÛÛÛïÛÛïÆïïïïïïïÛïÛïïÛïïÛ)hGIhGI5CJKHOJQJ\^Jo(&hGIhGICJH*KHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJKHOJQJ^Jo()jhGIhGICJKHOJQJU^J)j7hGIhGICJKHOJQJU^J48%D%j%%%%%%%&&"'&'4'8'@'D'P'T'X'Z'''''''((((((햁g2jc#hGIhGIB*CJKHOJQJU^Jph)hGIhGIB*CJKHOJQJ^Jph2jhGIhGIB*CJKHOJQJU^Jph&hGIhGICJH*KHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo( (((())")$).)v)x)))))))*ϸtcQc@.@.@#hGIhGICJKHOJQJ^Jo( hGIhGICJKHOJQJ^J#hGIhGIB*CJH*KHo(ph hGIhGIB*CJKHo(ph&hGIhGI5B*CJKH\o(ph/hGIhGIB*CJH*KHOJQJ^Jo(ph/hGIhGIB*CJH*KHOJQJ^Jo(ph,hGIhGIB*CJKHOJQJ^Jo(ph2hGIhGI5B*CJKHOJQJ\^Jo(ph,hGIhGIB*CJKHOJQJ^Jo(ph*** ***********++++ ,",(,*,6,8,:,d,f,h,,,-->-@---.........N/R/b/d/j/l/////ퟋ&hGIhGICJH*KHOJQJ^Jo(,hGIhGI5CJH*KHOJQJ\^Jo(&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJH*KHOJQJ^J hGIhGICJKHOJQJ^J#hGIhGICJKHOJQJ^Jo(6///000 0.0006080B0D0\0b0x1~11111111111111242D2222223333333 4.404B4444444®®횉 hGIhGICJKHOJQJ^J&hGIhGI5CJKHOJQJ\^J&hGIhGICJH*KHOJQJ^Jo(,hGIhGI5CJH*KHOJQJ\^Jo(&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJKHOJQJ^Jo(644444v5x55555 662686D6N6Z6\6d6|6~6666666666666677,727@7B7N7d7777778d8p888,929X9Z9t9v99999999999":(:*:0:2:#hGIhGICJH*KHOJQJ^J hGIhGICJKHOJQJ^J hGIhGICJKHOJQJ^J#hGIhGICJKHOJQJ^Jo(I2:8:::::::::::::r;t;v;x;;;;;;;;;;<<(<4<h<r<<<<<<<<<=== =D=N=P=V==========>,>>>>> ?ݺ$hGIhGICJKHOJQJ^JaJ#hGIhGICJH*KHOJQJ^J hGIhGICJKHOJQJ^J#hGIhGICJKHOJQJ^Jo( hGIhGICJKHOJQJ^J@ ????????H@P@R@\@vAxAzA榌u]uI8+hGIhGICJKHaJ hGIhGIB*CJKHo(ph&hGIhGI5B*CJKH\o(ph/hGIhGIB*CJH*KHOJQJ^Jo(ph,hGIhGIB*CJKHOJQJ^Jo(ph2hGIhGI5B*CJKHOJQJ\^Jo(ph hGIhGICJKHOJQJ^J2jGhGIhGIB*CJKHOJQJU^Jph)hGIhGIB*CJKHOJQJ^Jph2jhGIhGIB*CJKHOJQJU^JphzA|AB@BBBDBFBJBLBfBtBBBBBB(C2CFCLCCCCCCCCCCCDDD(D*D4D6Dٯىzn`ىىىىىىىىىىhGIhGICJH*KHo(hGIhGICJKHo(hGIhGI5CJKH\o(#hGIhGICJKHOJQJ^Jo(&hGIhGI5CJKHOJQJ\^J)hGIhGI5CJKHOJQJ\^Jo()jdhGIhGICJKHOJQJU^J hGIhGICJKHOJQJ^J)jhGIhGICJKHOJQJU^J%DBBKLMM4Qpj$:IkdU4$$If0, 634a $$1$Ifa$gdGI$dd1$[$\$a$gdGI 6D@DBDLDNDXDZDdDfDnDpDzD|DDDDDDDDDDDDDDDDDDDDDDEE E*E.E0EBELEZEhErEtExEzEEEEEEEEEEEEEEEEEFFFFF FNFTFVF\FpFrFFFFH&hGIhGI6CJKHOJQJ]^J#hGIhGICJKHOJQJ^Jo( hGIhGICJKHOJQJ^JOHHHHHHHHHII.I2I6I>IDILINIhIjIxIIIIIIIIIIIJJJJJJ J6JVJXJZJ\J^JvJxJJJJJJJJJJJKKKK KKKK0Kܸܸܸܤܤܸ&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJH*KHOJQJ^J#hGIhGICJH*KHOJQJ^J hGIhGICJKHOJQJ^J#hGIhGICJKHOJQJ^Jo(@0K2KPKRKpKrKvKxKzK|K~KKKKKKKKKKKKKKLLLLLLLLLܶܐ{{f{R&hGIhGI5CJKHOJQJ\^J)jhGIhGICJKHOJQJU^J)jhGIhGICJKHOJQJU^J#hGIhGICJH*KHOJQJ^J&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJH*KHOJQJ^J&hGIhGICJH*KHOJQJ^Jo( hGIhGICJKHOJQJ^J#hGIhGICJKHOJQJ^Jo( LMMM.M@MbMrNNPPPP2P4PlPnPPPPPQQ"Q$Q&Q(Q4Q6QmmmmmmmmmV-jhGIhGICJKHOJQJU^JaJ&hGIhGICJH*KHOJQJ^Jo()hGIhGI6CJKHOJQJ]^Jo(#hGIhGICJKHOJQJ^Jo(/hGIhGI56CJKHOJQJ\]^Jo()hGIhGI5CJKHOJQJ\^Jo(hGIhGICJKHaJ hGIhGICJKHOJQJ^JhGIhGICJKHo(6QQQQQQR6S8S@SHSLSVSSST~~~v~z~nֿ֭uiigiiiQ*hGIhGICJH*KHOJQJ^JaJo(UhGIhGICJKHo(hGIhGI5CJKH\o(&hGIhGICJH*KHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo(-j4hGIhGICJKHOJQJU^JaJ-jhGIhGICJKHOJQJU^JaJ$hGIhGICJKHOJQJ^JaJ1  4 and 5 for reductions of compounds I and II , steps 6  11 with modifications. To tie both proposed mechanisms, step 5 has been introduced in this scheme. The bold line represents the ARP protein and the horizontal open rectangles indicate the heme plane. The broken lines indicate weak interactions including hydrogen bonding. Spectral studies of peroxidases show that compound I contains an oxygenated Fe IV with the cation radical. V6-N@b:yvSTirI0ek1-4/f^z[ARP-I3 YTirv~vff[xvzvW@x Nv0(WPS:gt N ARPTHRPvg:Nvf@wcؚI{0 g:gv-NvPSZ{|'lSZT/f g]N^(uMRofv g:gvvPSS^ ,S6R_'`OovhPge ;N2ulTbvZhvk ,vlTbvZhwQ g~gGWN0p'`:_0NO5u;I{yrp , gg(u\O'`Oovme0~U_PgeI{ ,N N balg0Akkara0DordickI{xvzN^4lN(-NǏ'lSirvPSZ{|ZT ,_0RNؚv[RP[(ϑvZh ;FO/f ,ZTeX[(W@wv1Y;m_v ,vvO(uhTgw ,N %N͑q_TNvlTbvZhoPgevb,gTZT^vcؚ0VQ g NwmuS@bv*Y~gI{NxvzNPEGOpv9hǏ'lSirvSvQ(W^4lN(-Nv'`([5] 0Ǐ'lSǏ'lSirv (HRP)v|T_eQ(lWQޏc2u'lWZYN (PEG5000)T(Wvv Nޏc PEG5000 ,Ss HRPY NOpTvv(W4lv-Nv;mRQNNl gSS ,FOǏ'lS|ޏc PEGvv(W4lv-Nv;mR NMя 2 P0(W2uSN'lmQs+TϑؚvSO|-N ,Opv;mRGWHT NGSR0yr+R(W2uSO|-N$NyOpv;mRk*g~OpvvcؚNя 2 P03z['`xvzhf , N(W4lv-N؏/f(W g:gv (N'lmQsb2u)-N ,vc(W HRPY Nޏc PEG5000Ovv3z['`f>fXR0'lS|ޏc PEGvv(W4lv-Nv3z['`kl gOpvvؚ (W g:gv (2ubN'lmQs)-Nv3z['`kl gOpvvNO[5]0 2.2Sf[SIQb/g Nv^(u (WSf[SIQb/g NǏ'lSirv_N g[v^(u YHRP1\/fNywQ guir>e'Y\O(uvǏ'lSirv,[8^N>fr^irMTO(u (uNvTMQu8TDKm[ (ELISA)SvQ[;Sf[h0 O I{N bS(WCPD(Sf[SIQ>fq_hKml)b/g-N ,Sf[SIQOXIQGraIQ>fq_v^SN9hncGr NNuvўe'Y\TrSmmۏLJS[ϑRg0勀b/gKm[HRPvhKmP:N 0.08^ 0.4pg(sS 2 10-18^ 2 10-17 mol) ,kep>frlupOe^ؚ 50^500 P ,ks^gELISAupOe^ؚ700^ 1600 P0(WHRPbTAPOp5ugv^(u N Annika LindgrenI{N؏bSNNy(W5ug N\vNekV[vel0 O bSvQ[[@bMv^irnmW,g0R^(uBl ,Km[9hǏ'lSirv (HRP)vupOe^S0R 10-18 molpeϑ~ ,(uNKm[DNA,hKmPNON 1pg0v^SsSs N TvSIQX:_BR TeO(ue[SIQ gOS TX:_\O(u ,SۏNekcؚKm[vupOe^0S'Yf[vsNSf[xvz@b(W1994t^bSN1uHRPvT>e'Yg|TirSIQvxvz]\O,OHRPvhKmP(WvTTMNONN*Npeϑ~ v^[wQSOS^:gt\ONc0 gя ؏ gbSN^2mlhiElaeis guineensis-NcS_0RvǏ'lSirv(WSIQb/g Nv^(u0yǏ'lSirvPSǏ'lS"lTSIQ(lvS^vgTagN_0RhKm0g'YvSf[SIQ:_^[vpHV/f8.3^8.6ُNpATPOPTHRPTArthromyces ramosus Ǐ'lSirvPSe/fvf:yqQNOpvv OahVT^5uAmX'Y ,^irKmՋV 0^ 40mmol/L ,5ug3z['`X:_0 S'Yf[VSOhbirtSf[[[(W-N'`nm-N)R(uN5uZT[sNvvV[S ㉳QNZ!TTSM㉄v :NHRP~b0RNe}SO0HnVfI{N؏(WNNvez-N~TMRNv]\ON~N(uvv5uSf[V[Sel6RY9hǏ'lSirv /ZN (HRP/ PPD)5ugvel v^[vQǏ zvRRf[V }ۏLNc0sg~tI{NxvzNNN-2uW)TU\O:NNSO ,Ǐ[r@n}vˆ}vT bNOvQ\O:N~T0Rsx5ug NSv9hǏ'lSirvuir OahV0v5ug[Ǐ'lS"l g}YvT^ N-2uW)TU؏S5uAmvXfX'Y0 hKm g:gǏ'lSir_N/fяt^egxvzvN*Npp0sQNHRPOp5ughKm g:gǏ'lSirvStSHRPN ROOHWVYUOSuPS'lSS^ e.s-N] gY!kbS0؏ gxvzhf HRPOp5ug[ H2O2 T^vMNObGSؚNnm-Nb6RBRbo;mBRvϑ g[^sQ|[19]0ncdkShKm HRPb6RBRTo;mBR0VQY(WُebZPN_Y]\OBogdanovskayaI{N HRPOpvxў5ughKm HRPb6RBRlSir ,hKmP:N 2.0 10 -4 mol L- 1 [21];SmitI{NN:NZNir ,hKm HRPb6RBR0lSir ,hKmPS ng m L- 1 ~0SmitI{؏)R(u0[HRPvo;m\O(uhKm_ϑ0 ,ShKm0R 5 10 -7 mol L- 1 v0[22023]0[Nё^\yP[b6RBRvhKm,hlI{(uNN2uW݄:NN(v HRPOp5ughKm Hg2 +,hKmPS0R pg m L-1~0Wang JI{(W g:gv-N ,N HRPOp5ughKmN}YQy NfnN4lv HRPb6RBR0dkY ,HRPo;mBRvhKm_N gxvz[18020]0(W(uN g:gnBR/4lmTir-Nir(vKm[NS5ug v5ug_N>f:yN_}Yv3z['`T b'`0 2.4vQ[ (WIQ^Rg-N HRPv"lOSO^ir;N g N{| Z{|Muir ,{|MuirTTygevrSO,[N(WHRPPS NH2O2 'lS:N_~g Sr0 (WgIQRg-N,NN NN)R(uHRPPSS^Km[sX7hT-N_ϑH2O2 ؏S(u\OvOvPTS^SO|-Nvc:yS^ ,bchKmYy'lS؏Sv0vTNN^irv+TϑI{I{0ُy_0NN0ؚupOe^vhKmel(WgIQRg-NwQ g͑aIN0\g^N0Mohanty JG(WMRNv]\OW@x NHRPPS N T^ir_wvgIQmmpbX:_eQKb [vPSS^v[(ۏLcv^cONN*Nev`҉^0 Ǐ'lSirv(WsOebv^(u_N/f'Y[@bsQ_vppKNN $\vQ/f(Wuirdaleb0NMR(Wdal NxvzYv g8TDTSf['lSI{Kbk FO[N(WYtalgirvǏ z-N:ONؚvv b'`0TegNNSseg}vP̃Phanerochaete chrysosporium-Nv(g( }Ǐ'lSirv [SNM㉈_Yyalgir kYDDT,PAH,PCB0[NLiP NN؏xvzN(Wuiro}vǏ z-NT]N^4l-NLiP[TyZTWgevM0vQ-N1uNvP.lge/frTyg:N0N[vN{| @bN[[vxvz_N/fgYv0Paszczynski AI{NSs}vP̃Phanerochaete chrysosporium-Nvv NFOSN1SvP.lge-Nvr؏SN\[NlS:NCO20Helena PodgornikI{NۏNekxvz NN؏[24yge\ONKm[ Sseg}vP̃Phanerochaete chrysosporium-Nv(g( }Ǐ'lSirvSN[eg N TSf[~gTy{|vge1r v^ NwQYyr_'` S(uv^irV^8^^[24]0Sami SayadiI{N(W[DjiR]Sv^4lvuirYteSs LiP[vQ-Nv'YR g[vYZ~R g@wؚv1rTZ\O(u0Monika WagnerI{NSs(WH2O2v\O(u NHRP NFOSNPSM[rv~QuǏ z-Nc>ev+TZ{|ir(v+Tϑ<1mg/L ؏SNMNOQQirvk'`Y460 3. ~NU\g NN~T~g[YyǏ'lSirvvPSǏ z0PS:gtNS^(uI{eb\ON_Yxvz]\O [9hǏ'lSirv0(g( }Ǐ'lSirvI{xvzv$\:N~0ddkKNY vQNvǏ'lSirvvS^:gt$\vQ/fN[E)R(uv҉^QSvxvz N؏*g_0REQRT|~vxvz0YNN(Wxvz-NSsTyyP[[vv;m'` g N Tvq_T,NSs(W_N gbSǏ'lSirvS g(WyP[vN`/f+3NvePMbwQ gPS\O(uI{I{ Nvv~gQSSxvz[NvS^:gt ۏ f}Yv)R(u[N0 Ǐ'lSirv/fNy3z['`e/fpH؏/fp3z['`I{I{ _}Yvv ,gS/fNyuirPSBR0@wyf[b/gvcؚ xvzKbkv9eۏ NNSN㉐g[Nv~gTS^:gt f}Yv^(uN]NuNTyf[xvz0 REFERENCES [1] Marc B, Marc A. J. Am. Chem. Soc., 1997, 119: 576. [2] Liu Junhong, Yang Fengke. J. Polymer Materials Science and Engineerin (Gaofenzi cailiao yu gongcheng), 2001, 17: 173-175. [3] Haesun K, Harold E. Biochem., 1989, 28: 5714. [4] Gaspara Szilveszter. Sensors and Actuators B, 2001, 72: 63-68. [5] Jiang Taijiao, Jie Xingsong. Acta Biochemic et Biophysic Sinica (Shengwuhuaxue yu shengwuwuli xuebao), 1998, 30: 132-133. [6] O'Brien, Peter J. Chemico-Biological Interactions, 2000, 129: 113-139. [7] Gazarian Irina G. Biophysical Chemistry, 1998, 72: 231-237. [8] Gazaryan Inna G, Lagrimini L Mark, Ashby Gilian A. J.Biochem., 1996, 313: 841-847. [9] Choinowski Thomas, Blodig Wolfgang. J.Mol.Biol., 1999, 286: 809-827. [10] Ten Have Rimko, Maurice C R Franssen. FEBS Letters., 2001, 487: 313-317. [11] Hofrichter Martin. Enzyme and Microbial Technology., 2002, 30, 454-466. [12] Heinfling Annaette, JesuE S MarEa. FEMS Microbiology letters., 1998, 165: 43-50. [13] Mester Tuende, Tie Ming. International Biodeterioration & Biodegradation, 2000, 46: 51-59. [14] Nakayama Toru, Amachi Teruo. Journal of Molecular Catalysis B: Enzymatic, 1999, 6: 185-198. [15] Smith Andrew T, Veitcht Nigel C. Curr. Opin.Chem. Biol., 1998, 2 (2): 269-278. [16] De Velde Fred van, Rantwijk Fred van, Sheldon Roger A. Trends in Biotechnology, 2001, 19 (2): 73-80. [17] Sakharov I Y. Biochemistry (Moscow), 2001, 66 (5): 515-519. [18] Ruan C, Yang F, Lei C. J. Anal. Chem., 1998, 70: 1721. [19] Liu Y, Qian J, Fu X. J. Enzyme Microb.Technol., 1997, 21: 154. [20] Jiao Kui, Zhang Shukui. Journal of Qingdao Institute of Chemical Technology (Qindao huagongxueyuan xuebao), 1999, 4: 333. [21] Bogdanovskaya V A, Fridm an V A, Tarasevich M R et al. J. Anal. Lett., 1994, 27: 2823. [22] Smit M H, Cass A E G. J. Anal. Chem., 1990, 62: 2429. [23] Smit M H, Rechnitz G A. J. Anal. Chem., 1992, 64: 245. [24] Podgomik Helena, Grgic Irena, Perdih Anton. Chemisphere, 1999, 38: 1353-1359. ڃxz|~  VXZ\jn"$,2<>@BLPX\|~ԇ؇&,jn|ددددددد؛،؛دد؛؛د؛؛د؛د؛hGIhGICJKHo(hGIhGI5CJKH\o(&hGIhGICJH*KHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo(*hGIhGICJH*KHOJQJ^JaJo(2|&.:<&,<BTگt_Ktt&hGIhGI5CJKHOJQJ\^J)hGIhGI5CJKHOJQJ\^Jo( hGIhGICJKHOJQJ^J-jhGIhGICJKHOJQJU^JaJ$hGIhGICJKHOJQJ^JaJ-jhGIhGICJKHOJQJU^JaJ&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJKHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo(T^"6Ƒ*04N ̕ҕ"jBh^fjzbƯtttttt__t)hGIhGI6CJKHOJQJ]^Jo(&hGIhGICJH*KHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo(-hGIhGI5CJKHOJPJQJ\^Jo(hGIhGICJKHaJ hGIhGICJKHOJQJ^JhGIhGICJKHo(hGIhGI5CJKH\o( $dd1$[$\$a$gdGIIkd$$If0t 634abdfjX\jnҠޠ|~¡.024Ƥʤ68:<6:<>HJLN"$&*^f$4ީ \&hGIhGICJH*KHOJQJ^Jo(#hGIhGICJKHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo(N\bfpLNPRDzN" ڱڱڱڱڜڜڱڜڱڱڅvjjjjhGIhGICJKHo(hGIhGI5CJKH\o(-hGIhGI5CJKHOJPJQJ\^Jo()hGIhGI6CJKHOJQJ]^Jo(&hGIhGICJH*KHOJQJ^Jo()hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo(&hGIhGICJH*KHOJQJ^Jo()HJ~,.TV*, hs )hGIhGI5CJKHOJQJ\^Jo(#hGIhGICJKHOJQJ^Jo(hGIhGICJKHaJo(hGIhGICJKHo(0182P. A!"#$%S 7DdV  S 2A05100102b|љ:t|KdiDna|љ:t|KdPNG  IHDR!RVPLTEgvctRNS0JbKGDH cmPPJCmp0712HsIDATx^]v$)޴bVsv6(òzw.=]x.].C.AlA R^rw[Xme.Bf?=8b[cHdH](⣞6RrM!gX)K8O}=d}[#k`Лx t|?0%~2&$2rB8 6 elTqe!OAUԺߤ@_X3ٙ+] 2ôQ`Ǥ xćLm!8aWY&dräT je$͏1ąVS6)vڂ|v eHkE FTbHD8 QQ9e!pg(pWH0$%p~~$gYiMղB=WqwKɉ):\aĝ \ m3rC,\$2dW7Xf[1$lی!T@dTK>Π؍!4>c~ol+xg pF2!=܍!qc[cƯ'Z O7ϡ0|vL1A/5KL}=.lnihjONWX-!NY;01bJ73$ܿMS.14`,cV6ͮ|>\FH׫+<:O7!{SAJ;} Z.Lrn.g H0C)8,(HV? ZMoapB jt^)K\,XYKcG`R%!Kk"zg=hCbmUw= uq C26 cXrM:YT5jO-tsxc; 󮅌LF) "u3JYC 3`J mrW~!CxHNbN%d'25Ba 0yAOU UzݨWeI3"8J1ĶX ¿~jaǢjˊf!3 RڳQ@MF04"һk\G(ɲzrN13f:˨{;bhl3DĐnG1dVDz!9=!m!dFch?Z.9I!/ljSlр, G% IuLu', ZB PGp b6Old %BGÙQ)H>)d !K2F6=bH %hȵ,X-α;_p5*HR։j.W2ĕ*4SPLc$v&+DksG{LR?jtbeC!1,!ݖ3n኎fHqP3l*([gA皬.)χYx#.4wF˔n|LȾЭ'H*}͡H <]j'IA::пZQ.Tx2_6>ͻcicqOp0*/y->P/g C} T.6?4er^ȐNk6kc5 zM;?Shʹv=ԆORd7 QIIkZF:!Qo~mwݗf&*blF1$@PLkO쉉RR#U=bl}sM^"u2!I,O&㵄^!?ɼ< "F&B>zG+en3[s`_Ɛd;2*Y2/ H^+5Cp,'CDZ*>j?_&kYLfoCBN}w|rQ$: z7J%>2olXːŨieMHx&my$?/D3` N$\ y-enB32[xCt9!Ty, L֘X3ȳ CЭwR¨ Xz&"C⭁@g LK22\(ozcqO2ķ0pǐthS[iSi^!*b&=3D)OeIn/S틂 ]![*WgYvRC< p?Vscq YqR=TkZ[57M j晪k=?wSkkoys&;rxJ1S\1*O=%Q)OZQt{ ('W{ (SO=c}ʓ=c]婧1>U^W!!o*;`H#_=m3'S[VU@5{c|2Đ ј[{z#Pաx a ϕg}u p1œ"e5Ɯ&#WBӯ#Gs2Л"\#Īr#.'F*Ymv7Wh|C ~Y 4g;ԶrAv12d.+P}ː7ys-!+P}ː7ys-!+P}ː7ys-!?dWb SķSNAh2dH7,-u_kYQ']xW-hĐ I*m!I:d#3R!( m<}&uŖ[H="ˠqd b®ː Z3,ő3bg;7WXy W j_S2P 1W]Cz<@** 94ƣ%Z5qMPEvJр'M]F͂:_x{ u2%5ai>m5)OpBF k1d)Cpx{;Zl*:3M S'x"vSΐn1EC1=`BcY@q |Da!pˌk9?+ itR߫o \T+_k~hS_CZMݘ~co:/GJ telsU|vm̐$+]lS>jr!m$bt' Kcݍ(?9;A{!E=j҉ "(24)5 *V)!R!m,s>CZU k!.fMSI8=)%?wiG_/ eFSbrl?va$af`ezffSSܠӅ ḿ^[B>oF%U4rccDhjNPpPXxns2'@ jwjP1s_6D0g(r&C,#t]&Z|Cb賗 ~p2$vU(ӈ! 32H澁^VF:}y5'(e}\K;)'=Fj9zS O APƛ3N|-KY"5˄:!l<_qt6js0h18?dm.uJUP#r  ywܩISYHMz,+[ G רӤcHٺ Y)t Q*I8" $4|V;)Lv iXOkv^WL(h'7j6!.^fp-4!6&tue jm"Y~+0wbH˚#Us^fA10DĐ7jpur(vBb/D} OԳ|Z{bB희ҮzǙscncS, 7Gax5[vY7%I2cJ0c͙\Y+f.TKIQsf;4'*hoV srTh/Fl\|3lt fC{irbC$7\h)dN#ZaJRD$`~.{&s;z9 :(ٚ%ŐP]XzpbDE! ՅD7z* ]WpTjǣE͐j 90J- CjH[jݎڗ!BěJpxa׾ )q.Ɲg fňaޢ{.3f̸RbHvmuǦ)B0$?5*%2Y}fN(zo%hh)D9r,C= ,*Tl`iwpo+}!*>'M0S2fJIß]R;Uf)olC೧0C q% QQ` /C;)*0b_tQ^1F uΠU-zeBC*%{@,bQ{e?}x"SbL Y닄^șKL Y닄^șKL Y닄^șKL Y닄^șKL Y닄^8g."v2a.C>92.CV1-a2ѳX #R\=a?Q208ߟ[qD1qb d=C1+fM*!sQV|w12!.CJ5 z(WY;QlU+s}Yd KW)gJuZ[Sh^ϟˤLP^X09s{r'Օ3drmJuWleȦFːm\"!:f.CqŦ=xIENDB`,Dd V  S 2A05100103b7nY_^{nV7nY_PNG  IHDRAG%'PLTEgvctRNS0JbKGDH cmPPJCmp0712HsIDAThCZz0tҫBۗj 8.}6s!IdF󸌜:]8Eɺ&D #i(8a7,2د`v]!8Ҍ  _$?WC ,kGH4jFaʬոwQ2%TNpE?}&8bw#r#bԾ4t޳ui{3˶nf{*Z.f.5P^ ,{=GIENDB`#DdDV  S 2A05100104b#.ea6aUN{w"#n".ea6aUN{wPNG  IHDR|6NPLTE!!!!!!!!!!!!!!!!)!!))))!)!)!!))))1))111!!1!)1)!1))1)111)1111911999))9)191)9119199919999BBB11B19B91B99BBBBJBJ99J9BJB9JBBJBJJJBJJJRBBRBJRJBRJJRRRZJJZJRZRJZRRZRZZZRZZZZcZcRRcZRcZZcZcccckZZkZckcZkcckckkkckkkksksccsckskcskksksssksss{kk{ks{sk{ss{s{{{s{{{sss{{s{{{{{{{{ƽƽƽG<tRNSfsbKGD cmPPJCmp0712HsIDATx^흏Gwbj;P嗃T9Ss UR RPɵUϽ~lj85NԈZH '޹_'{]Yc,|>iwf;Oo̼y?yFd`P|>| xX/>| xX/>| xXuya>5*VYiWTOӏm8] yd xR:AHD]XD6SPy@17ߝ|g6E- ˝Gʨo?Q$ӿr]ZǷGkLaWz;op> :NCTh IG'MғހqTwI] |0я^~aA70xS;B G'ߩdXR,ό"&$]2tʄ{CƅR݁?EI"> d"UUS:QHd27\MAk&E營o˫tM"c5$O+;xhca _{abS*:_B˳jߢbtcr¿\3 "$ $ljzexDƟu#wZ'WwbB9eCjEva^!&P,,^¸1H ;kz˫r;!_7։$#!cstgr~w^+tՋ{1V={&w1gqK~̗|d{~=-tz&z"J/&Վȝهa}h$_VV}I/.D' 9Wjex(p Á/9[&j^@qv/a ]v`^'`fm_ {u%}W}|Bv3|*4smOC;YZ); @йN]s" :djjG'څ"1- i-l/sF9I`[[dD5;?O]ɒ$n]ԤDLJ qz_Zveӓ5ϓwZ;P(W+Ȋ6,${δZo>Ao]+*|p,=<)nͦ'ks:s{ǰ/RΡ&$|MߥVaM5jM0IB2Z-5{~ !o\uv~EdU [њd{&TðfZ  =ޫg/h},n[gp;sJ{vJ_Ԥt24NCT5"B׹r{ge9h|ž1\iwz~ޝ<'͈k7@fH/3u⢸҆௃yһ$LP,$B*il?gv'4I&gxK=ioʭ3۱ob_&ڭqfSr隨?fQ߾k(A|6=u14ЙX"1O\=t-vm)ogz)137@g,h%v#slmȻya4up+02[}LN=/D#;\^^ /o띪';u0irFWW|g5L#g JsS'y~B|U߼(*k=˰w}4ίmIcem[fetw@ڌ۞^`h^{&^~;tWs4SVVW=NO#M=4p0kA7v'ez5oW 0 K8~*/$_k>m_V0pI)XZUIw% }/Y;&5o[ Sk'a)Wءڹ=3|Euɠ:X?Y_Zg=.]Y ዡ Sz7 Cѹ+=j̷Q'ls{Khno^'p͊=$aJb~wߎ7-!řł/RɉU,X%x(2``؇r!x ٓK'.u p7Ǩ¯ 06Ufe-|wMlnk|[>SP+\Mn1|7t`Uku>9;XpKL6(e kBY||DHy"2:hϻtܪ )Un1:]Io|'|NGaαKV]ATV N6Jz^q|Wڅ,U 9rn7gGkqN1ԍ-V2ifDNo7clrٳ uN3/shD&ZQ.N' nYjpѮAqqX˰ &FC:\rɣ8\97 li^W8\c{c?J~Hԁ9*PuӒa 2zڭ9$>2 dr $թ$ a0I"?%$[w[9 jg=\MeC 7t'do)Mq]ܸ i5Mj_ _tSڰ/Ԇ2M—Aއ.;PwG;_nm& 2.®ܔ tJr 2lgoux Y5CT8Lp" ~9|ܚ)af Ws/*%U0%n}Xe֜JBG!v5E|WGI93}Cdڛ1gڔ!c}}tkh4%~LHkf:(G)b܎B܄d>s>NO2_wC_l[gϏ_ؔjǾ5<.jK8/a\!vevÏch>8p)tx\0oV?wFW0u}WfF-'<~BdX]C .H- W?S6gE|ZM&*mv[#&@[O'ēh7FD[o3nOKsmcxF ̃cf4mÏC_6㜞Ci8UyJ6_v`*|`*={-!g*1~2ͲG7Z`o:#>Lޘ PNaG1\Yaہ;coLM'hٜ gRP;ǹ{#v>=¿ [Չuz^6Vjq6JZ){{cp 1V|i0.<ݞki[/G@]~?=X`7yv$ MXᛄoeP*+s}k֌?3n怽%7aظ2̲/^5mWX 2B#H흫\NaO# )`ggw^viB5gۡzPMfYxwL`KOU݂ɧ?0L'Pc3c_zܡs'jxLMFM Nw|/eⲔ/VK!2:FC/we"!qrm5{wDZR/VV*l"{i>7!䲠PֵSZeIsWaeHk [kN\Kƹ3gZ<15j/ #gj|{ѥ;0ߢOأYot EgM^ZkǚV|fWbM:ɝVwWzqf脈:q'8[RŖ-UloeVj9vPQq6i޽~q |@blPR6[PPsڹ!&tkms:ZO z!yrJs>aڡ9|'YjSp ިxBsj8L5yy~k }2zcN8 da{|:=jQWPŨ8!XTEO:r|A\*/FӶG3:ɟ& B^ZUbpxx`q:\7)+q(*+[)X^}~e'婚fn#%ok7gv+\Cۆ/$m$z =$}*OWew .J 5c q# l3,[X.ZGE#W?``I{'|z6gDpbjM7F+'W ؟lЬgܷJLA퍭+Nț8ISSW0tZ%;Wob\QIzo, /&T>TI>yuhWA(9'ՎP|*Z;οxHx,I8_!O:WDIc_zZ:((=3">$<\׿JdƅӋ@V˘Ħ=zN:(RyC٥?_,.Z':a;3 rup`,88|v$ZΪ'z&:Ot" s gREQpŚNCGn؅QO;ZmlC!vM MYm(U^oq꒚^ܭ!G;*?=oz/Di讙1%3 ":4IEY<~!hoCMz+ܒv,6`>}W/'Tʋ&U/GN>@7, )$rY^Y> C%gij I ɏȃtlqJLV->"Qr}+Nt 2~&Q(AVw䛂Oo Ot؏&٧owcX !cñOSC1&y =RSV(fa m$*ZW|= /kf>vb;ق1DLm8M ѿiZό@+kJDZT;JKI  f Z@h˫(<όt8)M5+BԟIzVIufI 9/C $S?%>C:OMr1:_~.Wsx̑$Hroj*!crj|7()?mcھ~%/F:Pn'I? i~[;FF N|/eB:^'~_?WS;9F󽁿 *c¢iՎަyp{7·ߞr,u轡u> -c|no|_=aq7ߜO̧KZRA&Bor<ݠ}u{z򉰽j+~ 6%rT/.ʔs2yM< 'dWiqtiOk1LaFY{R!/ ~CkEwta 2C c;p#>̗߅馷ftXz鶹·CDB~:w.cHOˏOobm v/¿8],5wl`z}~䣦yP4p_a6ï5 owl0-5mW`|I&`(vS cVjR7>-45_꾂%1ZHK%? K>l{NXvn!gr=n_ A |iRkݦC`TP2HZy }ֵ ^|a=WY|nKXa%6zXyCVK.oiN| 1;+ Vn18\0X`']n >)&|r,C9}mѫXO@Lהb>nJgxq"MJFH@%7~e>@dq\*2=+3.[ >Epg<,36!ZDQàsV lv m(x:"Kfv_⑑5IH/I48yM4i@=T%F> `lFfYt<+2uD}gjcV.+LNR _g{fa?to)[#c 0C߫1M>wF4zل7v$e U+h~_YT4RL{gixI߁ΕW)4.d.`Tzw?ge7{&t~2*IIELEEhI\PwHRhEdҏ}@b#|%P#"X;[uEFp  zZ'q zӽ5JAhm5~R/cbDTDɛ'`BT8E4|"˒tJ!gS<4 H }zHT49JWs{Ye=": ʉڕcUIENDB`DdN V  S 2A05100105b0`MĵF"WGn0`MĵF"PNG  IHDRMib`PLTE /(/000?8?@@@OHOPPP_X_```ohopppx& tRNS\\ cmPPJCmp0712HsIDATx^]$W哰ĉcLrf S昶B8o҇I_QߒM$EsD)9eceinc<y%K "ykVI[h65!l{W 4DZ"٨|fgtޒl')XlYA@5M h2mCNꞛjEsDe|4b- }$`NH˒ j*E=ى#Y-?j8 eZ&k}hQOl{SM$zK;1,e:SstnN ܬC.FZYߚE f iMy9MԘ Xcag梤Fs^̇ȭ.^জ62]@7ф~Gzo6}M]Vc+߁6V_nKƗwXmSkܔ6_|6XGjﰤq0?# lFov!njz6pHW%%75ܜتÿu:#U|z2ImoOcG*2,a¬szek!eOjϐs4+GTpk@&+Ka wE58 iO6ttXVWygp#n.PT.<XS'yU'ŭ6ɡxbtr!=FbGZyըbeVGnf@97}M5vE^a^NuF7)fl% U'eC'<Aͅ[͵ԛ] 5"{]M7B?MSv+`lͧ4˗h.4nī~@sɻМ  M[h>VԽMB kC= *nIfgx0p콮c`]d 6vnKvE MbZU-?Λb7MCbgR]o‡Ļ3[qLzZESjaWe!@y) 4taͨMÁ-&MDnuW -k!):N?XjQҸGSoN #\n>&o{iJ(fC (`HlyU ;6 -ube#EGn)a\?~QK$4[ B+Imcl[Os:.(jV㦰 0Ŋé󠠛W3Of7i=U puд]MPȮW=N2&?ҬvZ&h-:qd׀)qso W/S],N:Mi4ڹߜɧM]P&4<Ҋ& 1U3Y}"߮TK+)nJL6)qS #ŕ$O{MynJ]XCDMK{}.olbrZ8ĭMhxW{%ځ=@ $b;,usu3/$\wո) aA=}!FONFk90? Yb+ +?ۆ=˗f تl94/pz 4,mG6jZ-Ϝi,N* OxZ~OڳiO VbAԂQܑh S8,e-x*)w>xW]Ҫ/fm*|)) ͧ8az(`pl<M ͩ1q?"gy2M5OQ,&Ag1NSr ,#+E'ns"ʚphz,:q'Lu >߂XMNHw͊ΩC.$/YwWC+nv5M!2W,_ S2 ЛF -m$KsVF^n1.:[VyX~-{Q~mp Mt8oxwIRZ TA%;ڮs hSvQ2_ Gjd|&.; 0YQ׈f#3=yZ'5[G-^Ŝ!̰&,rO ^v {nlYݡ@]>!m{u{} =cβa}m%CAs4`:zG:#|fy_8?Haek7-u>,踛džܻ+%dgm'xy`54o0[t)/+9zE?}MsΗ0=cnD3h.^AAs)npɯ;hC0{&Un(. ,j߈JޡقCh{&1*ÚЄ'R^U7y&s_.Å8HznD7 slWDnWM>r3ȧxl eXf7o]]Ӏh dxMDYN biޝ_vUjT7Lq5Iӎkh'm 790oy}9ͫ DSȂmho{T/n6'i׾ мsf_tTem)ERoK׀ތ~؀U X&U"ބ[ڶ Y&n B!R,ƄO~xTĚQ>YfDY# r=4v/֦fТnJ}҂cZ|m>? ) "]%U"o.nےCR0h=r$0PtV?+-3,vK:7Njix w' HlO{=3~*4s-X=oMhߛ[߇4-Ҁލ7K(M#A[ |?7]h2x8I_ici@SU'x&pL}M^\T o/qM.xF]R ê_hS?7G^3~*ch g^ڎK{q.l'z8 mZt ᕗ1L-q3yZO􅀲 QЄ36>fdzsx'(ǭ B.@1l͇֫`8RΫ2nnZwPS _)\r+<#Bzc8t3OY/,JvyOf$#Ěs:]eLj30-#VX1yg? qϫ>\IjVE9h; & FFY:Me^>0 % D ͺД7D2(߇E"tBH"!YSsg"l,!b@D%H|#seA]D]P~$UPY}fx6)K7_7߿#j}0QI0F30~3oEE-DOa*0oxZpJw)3Bw鋮Y_ÆA&×_&1Հ溤is.r9`ĕˍ9]f+ff}ɜƛ[xyG,h&OYMagSFV. 2MDp?H\KO@#ެ f37+ꈞh\熔n֏ʓN@(?7n2+ɥ4I;DWD]`FjY&pC7L[3R;7.& jKwLwNd>h_XSߺLְT kV&v[IWNʿ4߽+PB;zu/iIENDB`g$$If!vh55 #v#v :V $6,55 34 ǃDd>V  S 2A05100106bTF$Y?y@enTF$Y?yPNG  IHDRQ,PLTE ' /(////000070?8????@@@@G@OHOOOOPWP_X____````g`ohooooppppwpx)?tRNS&|bKGDH cmPPJCmp0712Hs+IDATx^]ZJ0"xB)ٙHuW%8#$VU17f 93?T영?X6"'?∱ь8w T*Y9WQPAy&Ӿ?X|hC LJ/ԯBBrS/=! XU!zt9V|b_9ޮKBeh7ĒF&X ~Z(RAd{Ʌc2K`Ň7,H( Ǖ3L~Re m"iu}!`1zQTk颰"iŸS'dv3gwI$]\QP"ĄE?br#x!16iS;f"(ӣuGl!xyN/gY :Gf[D7k[ >k9Tt,rEt" ,YCAcHpYOHx[xJEO;x:1+II򨏛bQ.WOi.]1_K-o,1f=0ҵTn#+N84un{t]ZjsB7B4S`?,SvEAP^&W'3|H#,C3;,Fp}'6nΡ}9ŵ|:'vgyp;O -DI5G2UKW"-KI'^W/YBD7bYƲ6:&8Xy+2[F!W"te7gm5\bS-2 . xb{n1aD$HP:Y$QfTr il h ~5, 6!+ZSҘ %Y71S?Bs# [LGJczdcPnv}_ ~h˂f~$`nfE\.y99F=)8L6TTKHYsjXp=n i e2OJ|Gr{)(hX+\tS NKE)4oW適{C߇?ޗ" "N3sEDWcVZ 9~հ.t r4PaQ-tƾƼL}-zYMv팞)r5'$,S0Xv{ĩݰȬƇ&! uW  aya`,"%USG pdz]Kx܏]w9 gDZGNj|߃ DTH̞cRkD4>#?X|? OY&"ncۑYwx/\a-n-,Z .Kǯ)ZR%`޳*YɹeEabDw#]ċ\{#mՆ݊1Z%~;~(%ӧoI 1cg.5weL=}Zg=X;]0M 4 ~ y[Ve 2-0, hp8!NcXpRIif.߽YbY‹OwKQS| ٿ7+!Ih'w}%CaD:!M~'CWprG8|w>nXDA0_%^8ς72BM4SCTAfՒM wy i.lIhml7nb1ؘǞ;4 ؽ<.XB8୬/]a1aZ^:hL?5?H6,ҀԉLSeDEQhƎkJ-g\wtx ~#_ QJۃ<^]E(lǰ( Ƕ@X9vg;.{. ^r?=x=~_sK9E/Dybvv>GA$~=,)͇.2+h J/`p,&xY {c: Q pEniރ ~+1OV'7"hp_j# C+Y;va˝ Pb'\cxSƎ+=.MyP[<xuVZ!%z"),i%`'FŁBnʵE_yߣd /kj GQMP=T[߯B8d?Vn1%ǝۜ q/u ЯDpF!WەӠ0LdoI_Ž[CyU)uif$*x)o'z}UU,=͵> !UjgfK4^}g:͙bkup׌5:2TWYp;-jVj4 B熍J4z©+l=sRDXdRŽ]ސ<-ÿ{?]ZDs`NkF?Z9Vys_?B\CD/dD*qpS-1i:͊oNxay҃Nq̶\׏nn*E c1DζD -^SEP8ASBAd`෶߿i8,LkW,9dŒ |2k!j.`,9-W@DFg"ǃoJI>"| x5Hac̏9r[`mUPa1jDY}*PkMN~?-f1>Lծ'--DLoŘ`/B3@rF&.)|U8;ċl~9]z>~=&If*B@RNm 9?G`fYMyݝzG =ǰEX:ceqLrg?I[[- CDĆ#."V8, +n8"z".PsrWaD85^ijܩmvֹY?y*#X9ΥCqrXRHmKѧf5(/!qvS `B!LCf_~{6 -?2lzBMBC[~M8,!8H0 8>rsE@ 7[ 5}7HU&fѻ"GK:$HiV 9m!wN:5,B0hˁB0ǭL*G?BN͑/T}ʀhڮ!Am)pD85&.$T OKuOQRj?fܸio*jql"c-6|ƑE+A@x4#x;vjbwJ2.i.ӧObPe64>-&SoNDxxv#)tV։`}{Զ.}Ur0"-sB%e:x=`<+"yXxq8uRx0>q|pby8Y;L/N jk؂m*hmDېm5w~P_[Ut? YC d[d9yLR34q:)M n=sбHDfލ»8),464awX=-V,19 z0#oJ*3xsxiP_ bqw?)۸ 5,6 aľl" u&wT&LwOkXE)')b W$n`\o*/P41Lt;B' J F[x}"P] ӏ WTT~0N =drР9ނEGDEsz&wJ*腼P/ p".=2K;k=]k|U h\"䙂 &0®BeOyAa‚Y;x@Vxǥ})aQX;$>k1ē>V63R,G k7􋱙>6 %@^gb]*٠ȼDQuw=1nc'Ps҆AY@p~-p@A㔰X+CVm1dWUR ,zp^+ էMg`N*gdư=S{^PyM#f3Ѷ;3ѡ=l֡*f7F>ʝ7Apu/RG"_SbltBķ{/?GC>$5cޔ5Mlgi8)3 c3GѫCu|ۡU!fQ;GjzFpk >P#d!nmPS }\#O|?N >#/wDqDV@> ᇺQ(QP7"JzP?;xR"y^ `-.q/'^)slmi$eO$}ȏTӲD }qb T0 A D҂g#S0SEN $bWUOw2+A"w8b>̫ySp69Ԑԭە\*bA;)/Bu;vaNmz2D50LiՒ-3x? _@pN Wڗx~)a*""dmt[_T&r\ B8̫v1I ֟O"HGa+f`z)wan:+eO܍+oS{]XgT=%,ΚvËu[7ehf[b{1(]Z*|ZP9m[Z}Cq *_XGДZC2{x. zjY  ;.4C]R{3&!㔰].6.6;D?Lb Em[e,bC[b3`&,lQ!>:0wtoɃ@a3IAsT =?B0 Qĸ|p ѽ3S씰hI@C܂xa]BL&O3,5 D`m4Š6HiAتd:J pz TaٸРR{j霜07tv׋(9У.ψhr٤n^8@Y HrxqJX 8M#D&V.FA@A"d$BWd9|K"'I}P%Az ܨ2ҁ x mvMpfi 8n!e h4oSb ]VFES0ZʍP)Jf~n< >I5nSd ݻDH-o8,!EpvHޏ.МcGfBs_*߾; }K=A@nB$4o, k\gL Y#,B%׀YC\IVT28i_1m3^eRLO9%,b 9PA%qfB+O1sl_K'*fc=YG~KVi*ðp@#"9ojN8Nhgh-ك!N  w\K=ZAs/f$AhH~h@8}h4YM."f+f{|Zd& vn|4Ǫz')'}`TMq.ę XG8fuX6,SEK+.B z(&c[=#HޓQ4#+\!-WY 'dFE;RRF| =}j T U'+B 3P] ^.QLق9 fH!l9Wn[਻:1,>ǓK!CdTkx'ݳ_>ܑDT \t{ мx1=9ӄUiRKHzhCA/\GhBgR>x3kj+h\_ ˔.}JHP Dr9qQrB~Vj҇Jy*e !+BôD㍚.G^y_ #N0" s\x@F/O},zMx&y/ݧel\C] ؜sGM k[F}IHJAa~ˤr@a.҄S"d*xlXb19995ɠ_ϥ}5+fң~0X"/.җ"]L &b7鎅1[}ʙ-NV>ETaAP`ы-*= qtLC5nhZsÇc "Ћ5³_d$X^"co">!XY)G(˛%/BNX"1*Jh1ޑx&7| ?q`k_$yJ's9~`^{j]1lP.P-pC|u{d'7AxZm٬:{"ɨWFFe9. lVsùeY}XkqY߆@zKSY/>bd  t' *9Q QG! H;Ago-s2_tU?a H` y(ÃI=\t4!T TDN޼јY^0 蚜(7o@B]H^,}TpK{ynH cv ^>1P5h R4_((2{eaݲ= T>˼LsbX.= f;ӆC>=^!MF}"vVʸw;QPm򵷺Xť׿DߍMK8D[o/ RcǪ5,4G|$rAeYq0i*-Io'Ҝ5S#earɗO]>MKgx̝zw[^47\FT}a 6sغ^.ԕO$]􏀅ˮa4Y. {[Za"ƌ5\gǛ+OHq5MhP,+粫E\AʾOB- p=ŧ8e }rg% =Xu c;.x5Du(YኮdLk]u5wy^*V7^Qa [@PxN;F=MIO| @C}A懨/pܸ,Lu4)zrOe c—0z<;-&,Hͅ[G0R-ۃ>{ז.nFH{(z=>q7efX2. Ll,3H ~GIPW&KHwsظ! ,wF+\ÚA͆)xxm. ='sWG3ZwFP+X=!RJY2j:F`./)G$d֏)r$ WZ,;˥373y\(5 uXJְpqX-}PM86x0t)V C鬣*2Fx\M`'q}OH.Zꮪ c;Z5}a3"^tZx_C ,z׎qe#Lx?Lu*'X7ͱ']'@\_3ɂcJԐYR7k.AV @j:?l{+.uV>Bf;q2%D7I`, yeG*9=ljuj(sق]/kMzf 69Bl9%79nr{-fZ.߇T`Xܷ[Ρͥ2_۬WKgީ ak&Iͫ¸494E@;aP,8"29:;T0@rIa/dc^(˅jPUk(v#ힶO],)]Yž;5ԺvKCC]ĥQ:`FC({&, pcMA+Qđe~n 1轜"\y ;qGm 3ל*&HJ~7./ˊzykx0iُx7+ohsU<+1?dTKOC 7\6҆Fi {cKd/rQ&.ޘc,QqgYq\erM Xn^ۃf0a%-ˊ|2O̚(Pa^nnw0ׇoȅ!6 bb;x#U($lue掛ۃP6Bp=폻xƣIeN.9 |`|(,&%WR$TWZ7WZbmǽu{K< i6ǃբ˵zմX(ᢚ S(Z99"wCDW;r]m"Eey|q%CȰb1e~fq\N{>|:PI<$TG#xryHg9:6z|鄮 jO¦Yʎ^esNzv{!4L7w4؋($ELNc /aaY&O)S I}d{H[O-^^aRE,w[#ޔl86XVxHTt=}ዖxeXՖ{YX| !Jhp w7ý1O↝~A!=ҿ1H&&]:ۅ'Y_qzZ&e_-_SL, \cYE^C>0[gpe#]XC!қa9`x yO>wicAEr~=_ nvxWM{u(vrmzXxQs>fQ+={6Z.mjV?k+mF,h|rLՁ]Ǹ 3K k4~PD'݃7fncsy8 n߂.3|SƧŸVXX;/VI`׺'ʜj)$Hj?bjLL#D%1ZLhCpPpn.Oiݭ55Duaa@59Kж#?w"PS[UD5d.qs$Yog\̇^=|>DIj&͎+'Eh H]" (R]qma"XD 6bзjm0tv|q:՘*!x]]޸K99Xc^3V'd4BQ|,șw^:`O\@~rEe(3: =\ʹ8],%gny;sQ鉠`E0%סBL$_)5q[mSbДzDn>]0o"&?H'`&j0 fQ=iSujgvgiOW*$4*jePmmh;0u]1Eaܢ-rTF5Vg1*kJ}S⟏ez|P!{Bߟ,o$X,-EC]'$-0,GL)5-_6>~^>2)'2k?wyW4î%$[4@g#n?'ƹ0A[d]V, I!S<2o+ țL\@rY|vX Ús`=xLvGri\3=nI TV~%Ix\|"aΚ!$G$7}1E@L@b(5d q^Z&ʦQQ}k3}(קR9 ,sܗĪ! N>AMNWδP'sl㓄3ꉀ td`J |Wʏz 5eH̐tvKpefN2؟}Wdbαz>ҟ2 n#Pd ~@:ެR^= \/sWÑ(!6Od,Y"EZMW(䐝Mx1;rgP!u*^S%hdYNb{@:"?m/]@d$Y.:h %ⵋ?:UԵpѭvN彾>e) n1dYI|.XTO67\Z9@iתRiyQ]yxCL8w SЭRt?YyݖIGb(TNBR§oL`ܥ5tݨAτj#}ͫKUeٹDEUYO1Cɡ\_ȫ)VU'iv:_-|ś -m 窝}{)=|:Q!J*@'-e^RCj;Rs\I'^t.,;Pz5h@E/>+?=R(j%op;|]2Q##{?̪ ++?R"[#nM7?ÈG~ת J/;W >9*NhSt K轺a\e;b!(5c{w;f~p*Y'V`|yU'gV,xcgs[n%yw tL.ݡ>m6 >oCqG|6\iwG_=' Q}cYdFN"aW2EXQ(죑D_G j'c Z%D0I?)z*S`8АM(pCL&8b{v X,d$pmpcXxC56rWFѸɽjj,<53,O+?c1ٛ 3ee2 1zMA?z|,\7 ,Ev|NɺڠE9}+tb0QP>U% f#.xS:vAg[5:g?RrY~y|WjM;Dx}fiA]96aM}^jUG! 1CP0! Ft<9,6Ib6knM@D@6%I8i8bJ&3ht ǝvXCҖ-u}ji|()>t KKAx}/dur>|y O>h1nd @NDm9&B"BJL) =ANעyFi$ɮBđI`+V d:+ 3N GF5O tBP}v?LJjX&8,ֱU549`(ٴzrh-,Xi^C`2n1]K9  SނyrEP*]ȵa";&ѓҨPK$r[2I[2 O'[ʩ'&]iLc%ȡ#ϔT, mD"9n"h0׳|1'ۅU v""N{X89R&X4}1AIc>mu k O4X M>+*% Sn0k"*^\C.2)(;joYgİа7nO siCV4L'b3u05q6%Dti:6H' $xA:?_ՠPRPsN` y0NZIv'E_4186:ADZ¬TRuB7ע5ݷ`qa(v&ZXpd׌~tJ O-v*2aöæ T4IxБBЭ3Bz&DȐNUJ؀!E5UZVO9`'r>皆RB(jq;%C`R'ok H,SLuEcxZk(."|@x)s} `[x> =+;<:g^stO{t Y 2\C@ M=zx%[L`ӧtZX#: "miS2{2]DEw4*pXG]h㥦n\Fa2'GZWZ+_AӓS[sNd9XO ۂ@:|X:&ⴰcy xSDe9B-T\C/R])R癯sgiw9 i+w /_2i;>)sѾiSaQjmX6WAN yAxX|clbt>Y=xIvy" Y1l<_d›}}PŢ KV׾ Nk]TU }-[n:ȶokq@V8ӆ 1P2TVT2cEŐ$6:^?JW$5o^-vw+/fGArF1xo@|`t / YmG!.sdXBot1O5;>A.ăE"Pr>;1|ZX*ȋ"L)w[-率7';VyH/<;wKEW`9;Cv4n5=? : ~h>$}MPޛ b&P a2AJ|O:5,`8("׈lE.H7>Lȼaa& GS;έPG+'$v h\:~5HV\IٸVѱ6`oM$+41ϑJ 1xl&)Օ25{}"cr]^ Os̒-#yQF=ε>2>;㧸m"2C'ڃDqOغ"D} d78ɵbY1#ƭ@|d-ށ;"v}Ɗs8H 63,l{.t'@.wȗqc_xNd~ t_>KP˩V/!N(_"?@B%n6g"aF\!=JRR-2(5^H>\>i *#ͳ'<:CāaN k9X ?<ve{wP0[}WaiCɳ ԁǠ*ZY.NH[bTxc'DK2';).MӁ4}2Yr8!;hޣ(d{܋ 14 O[bT> ٣6?SCcº 8h7.dOcYvg>$%OH2(ȃ6K<"U!zl~s8B7lo!V"<` صm1_]gp럚<&cA!궂O1SVt Wx r q rBlb᧸KRU@hՒ"jHnExF W`p\ WC<4H" tgܳj[8N)nKyHԃv hzDA=w Ս{o8{h bLix t1&!"bPy`"p"l-rM ?/<\ׂǻ\TϘѦ*6Ű*+;iԭ? A kBD0vzym8#B:U)1_UERfppẞ=cھ넞D MQԍi4\׏`2p^J,Pe^)I 26J;a1L)ҹ%_eq%I0CМ ᅛS<jj,3 #{Uڦ5sЏB۽[ڦfMe^^g@LFןb pP^aZ.Xh D*6k;HygFT)a#T(9TR.s[wY. Wxx>sFGZ#aO *5nUTErg,4r%-6.&KAo-+c3^*HHL =4<4j6v8A/O8܅mmൊNWۆeU(<9A9يIw~rz/1>-v^Rf;0'xHop{Ӑ{$a_ VYR!H% O"2 oIC̓} g=S(yueO8)BsyT2غBz ̴L> WD\x"XEk אhSAL<6GÃ@Q.\Fdxim}Dz;__nzjjEt$3+D(Ɯ.9Fqsս^lE )%@م;.UIzyǐ3l*SH޶ۧƉX@jx7}M<.Qȇ(ҸVb_rceH!^cg"m}6`:Ld۔ow{vFf=ZyAzgIb a#he(`BOuX@΁ 2Fmb?qsZPd?$v3_5UQ:ysS[qQ/GFLC=ݼ`w)U_ ب(IŪnω.kTǾ~;p|+# #pzt,9遈ubedٽ0 v=د]9G'9|MGw1u^72@Hٟ侖Κ4{=M@7Yvsi2Z!JlP | jᛞapÍmQ|-jX^{1W]Fon+Hy;*_*? ?t)Ut.rW(ʛJ3z*Z 8s0#ѱn <ܐW7T)QfˮzA )Iu܀ӆ˫s,xMW W`D7v{8&M?2~,* 붘77Zte1iFMY6fư/kSY{n:/Gm"hse q]]]pE6(j|nҶvU;oρhh ZbvbF*)4 DzŏH]HCtTQKb{]u=wjH`=0i|CZ~,ģv 5!@d+vo zR A /jo b{;PC`;6,fU<|v[̬&i|hgſ@'*@P pkwwHwٯ_;4-ɛڻgB``]`bZ (-lO'OZ &k|:%#AU@'Yo<$>858k $bb;#lP`SxڧMVc4%%l3/f)5xpQ?~/A*qcUO@M##Q׌,&̈́R:5*z_OF/MpG%/3~!,dknMMT`7O`PGM,= z;qQjհT]c5qC2 wX7+I2@dݷ|_ g}0҆"z/0ݶb8Yh0x^DٶH@=Il%מjn^:^@:]IEy{Xb[j^~n7C@_!qlCݞenIdTtYqs.G54^pIתmKmgRs D~%,R2EgQ3"2TzwxV(ء AF;22 6c.arKUƲ,˜* M+G\9}z"ӜЍ,D{4p/,>48 ZWD!y5GObɦ^HEl/T&H*$$ўۯ0nmu?8W P4ܠkcgڬe49jD==fMzGEz? t 9ght(#樅wpIL+5!-fmu^mO+U{yr,p"{(ŒN2t8>Z*,ytM[R[( mga֨hZ,ă k{F}<^{1 p<-p;-įgQ\F'[0$Y M2i/`NXt̰GX@Z8D"VozzFt^'HVIsF9:VDR1 4!a%-ƉgV6w TFnX8qɃJ9C P>j/jh-ܫ^iA,q72%~&"X_h3+K`1Mz"oIYqm銋MoVU,^`jYPvBl!= ޿Gs! zB+cN2 # 5RGӺ&uMA` ~q&y7fM!jq)*5c]R#"jeҷե~&,XXݕE=ƏiWUQF'|{?:}iSHel1A U/&)bȁԫs"C8ɰ𪢾+ = g&:0yi@1#Z`-E7 ,*b Uq3FIcwZ/ev|m ! E^ X`Vԫ2'=oƲ,4@-cM`,-Ŧ*jr M,v~c-Ƿ/16;" a1qWjo'y:CQZ ݱXHZ' *iQ,ll"0[H}bVbL9y_HwՉaqs5,*Uu}/-9,K^T#6vi!iM22 NP<}f]&֐ȯ=l"ON˗qI*?>E+WSEbx%# EK7`AjF+H 3 F-Xn[XTƙᱫkȁ~ppU,fWTܻS ʢB*sDL|*N\k3x 1Z#!jXApgӿr"PU37ƶ+5;3QSa5Gd|ԡ}x~bGY,*zyGbN/b2B-- $`}҈zFP{d.39J[աPgڽI a<7\/%kx}/M* bS?c>2+@TG6XfA=:t[^aGe{Yc5M(pM/Qa@M7=OΤ{P"Z!Rc[Wֽm3 W[ ZIlȅ T5'HB~8xI<|`_/2+ȉ&J4jC/3uVY,ހńQU) CGkn±OU[y>I NUep3b:7w2|y IpdI ܅ |5w5e \vexW%`et|O,w];'6I^\ h¹P-B ABv>M;Pqv5DHҔ?-5v1dn8-hw21`0$x%h'a_;D0+bThj/fF\zfT\{Gat)6`!19PC mꤵω0SKXH2 5ӓϓػ&l*o@ЂeU`sX:Ɋ^(\\5h / ox50+i$D/?먬S17rMVj\JQ!v)0E~t+<\o]jKXH D DcAW,a7ټZPdSԴɨx]Y+aW2?9ɕ"G"h72g ?X% ~(ǫxT ci 5*T"L),D,B,V hz=bH%'bDCR6`JZ|(1ѩ@F+$Kg`>T\ Jh;p4R<|qҤI! iQ.{΢ əN?X-*P= D|ȶJe U.oZc+LseLmea1T;H$7-/`sK۰H)уARj۔>hWř_\,H4kK%eIo* :ixK=X6!bnqQ~,Q}FIfE=Ս eh~&Flft> ,R)Ŋ@KM2PAi@Wԁ"= <$Re'/V<ڰHA$CFHc:Ė #ZM 6 iaBZ<)WH*m2/U*:Bo"$,^¢T@<Ղ  <&hվ,#d6BIS#6"P!!+Wiysx!} # 3KY%6Iq̇y)Mnj$mg4A !p g^#X~/x9:,Iȉk)5#8ѪFdeR1P`` *():-`nd /,ykAw.5q:gXT?H5M,^=KI^n}Ȋ1v ihB|^_@r F]&G+K6W綥{p 酄@W:d) v60dxH#-ίcςhW5^B֪nE&-bO~*v^R tB+`,@,IgӲȷ 'xW&EޖwGJzj,w, d<r!' h$= ~}ukwBq6>$5`QM튍QEE+9/}qM@j(U9 ㇒2Ej$ܓa2b$(wI ՇYR_! %[|Xd>l_n]Y{bv@aNĭ B4KA#>a_WC>ܲs~bg,W@)=(i4"FkT'+t':EA"'r~"6`wU4)U@3vC+!gcyDr&% Tg?ZŁuSs7k;rnw'ؚ0RnjX7J%EQN;#~!,^Y F5-/o~+xI_}Or8ɴⷯI'11[IENDB`KDdV  S 2A05100107bJ܃b օ6<JnJ܃b օ6<PNG  IHDRP1pPLTE  $$$%%%((()))***,,,...///000333444555777888:::<<;~Ȉ/WD"_MSMGp06K5NЮ:v/R@/@R5ҖJ13`=[ 腇5-TPTHq4 g[E^Uu6$⺁勶(r>'~/Z@mF|^Z@{&:4TKΉ7ֶRho,lrqɥ #{}{ s71ml~`fnoji yj (0BX4P3v&e0nbS(mx0*Ё/Fd'.,Fv㤄P9?:aQ:i+F@F&"=t~HDEE[7@Q ٫3o.n-j" P"&>6cikDT?@Qx^:O./IG@*Eq|/G [񻞀Jãxݯ'iB m1_O@OW! C'}UNq#v (cU<PUge+FTW@#Fuwvu:ӝPu4֥Zˇ@ >Og*1]5HIMnۛ6P(k!W)=RLިz (fګ (.':Y{42ubnVB[ci'Au j `zMP+*#zڎzE-@:Z=F:F]evbPXkg{ꌧ{JW@ч'oU4;Ϧ/ B?瓻hڥ=þwP:sہ#6 a@]&a8-: vPJJwPPR]a#x.Ph~Dϡl՝ۍ-_҈r)owb@Ǫ:I wm? p)Abݰ' z9I9mmEwKn(N43mu#:&9'ϖʈ"J鎚}-.Dt/|-4֍4Enǖ?۫݀6}M ݀N Tn@Fj@;Eo)1Mo5oT̀VE7kmL,ܧf@3è;'&m7*JDNhpCMՍ\ 3 dqѳϱ^)gLWW)TnKꅂP3}ܶ|Ӷ Wȴ;^W?"vzNMI^Iy 5RĎYAz';u5m=Ԁ3:L l_ɷC cҫfmk3d1@E>O+Lf~hcbq@aX4\iOWR ]ط<ݢac~Wig/?Y@X٢ u!Q;oc`i۷;^fst:mPX'mph}zw0pj1E?7 (:ߋiu@>KvzR+} bnjH+D}~Oru0f"uÀf*ɽz)4oeMUsOMIIˣWKD3z'Gtӿэ[ַQ(xSdoPܫf?=|v~ros›GnwtS[x1Y&{/|kFq!&tŁRbi@):벣Q ,rϲ>+U2!gP1G~ 2$:1!{ZfBazS!̚d5273W< oXkK4f7c iAޘ}>}EYQ'nl> eizV'@keM|F+nL2`+1ào[ ai 9C['@7I8|Hh !ɒ@M,֟¦][GF Ppd,ު~4V/1x]_v Ũl=4Q13t{lIBQm\\QZ%bLyuǪmU~`9Iz$#M?$>D=^¥DrA3Whrᆝ\{2E>q]AN q'X5O':_bf{Kw;8lYֱAhF4 Cr7) hGN)) C+xBu'YJR' &P|M}CΘ{vߥ%MO)rrk&X\ˊ6e_ʩ?̤QKA'=dmdIl)Ұo]vf}i(-@iQYۘ/G#TaY!C9b܄x΃pq M8e˞9#_\h#_`6}7zN<ȷ^gD!ո,3In3GbH{|ΈC#R-~Ep" G6д|#XrԑB|X+Wq|O "^WR@GMb])mU20T sY4s|(oFQ {PW+KY8A#qhOtC=E^il;bκ|s~cnX5Єw)%RBc&¶~,+| !}I yw 4׮,m1{{o5|fLs2AV8_Dtoɧ_%O^(PdۨmsvE.^еZtQys rTz&of׋EasƣIo4c=6:ŒòVT(6NGȷOVM)N` |N `UGabTL{hg ( QrhG4:{bnXi/6i0ž "ib:"OCxӗ:zN7D5u}kKDLRkrR}.w Jr0'|hc|_s-;,Auh`?n u k_ID*L>^|:*6Rߟ>Fzƒh~sOH ep#5bR\^M@m}orlf 3BN31mn8Z yΉ7izu\/IWNꕼ01)ۃnۋŰI-(ߩ_*7hƛ g\ Mr`  *MWcKݦ?[Vˡhq uЧVс; *A;o6x4IiB7i`OTZu({"J߲̲[I?~}`E8^uNAH ahjХ95W׊ 7D"5MJ { 8#ׂC7{+xL^,{+3>\C_~? y&f7AJ]{uG_ĭȃy&Ƶ-y!F$}P &R R*>"Mup ՘o TFe )bR1zNEc v8=EK<\p} 3 D3MEumo7r+FTθ7TΐSehtb3wa-r6z, hU oRg|WGͫ3+O 3VMR8(H=t\݄kI ~*ek8s9ipmh.G,=I+ӕtYx#e@;}1E7ù#k ZjBM"ѳ$hMr]HW;%4SSX|CeU>[X >5[4w\$"Z|Ž? 0!>@Y zUBGO$yr)!T];FLZǕ`(r|N,7B2o9OsL`UP(}sjl{TL1ʗ{/AqKSaf쳮NRjANU~ɋE`ƝsL~ڝ}ԕkWĆ$sQ(GQCh{E#BįJ&Z}IT| 5\ןdpJ%1K\2ФAJ#,5~MrATv*R菆͕@/ 9JLkp@SWȈ@(JUŅm%-%$ Y\C~ ։jsb"}V"2}T}\̮f6,F3`aCFK˷1b䞑p)Ee2''oiLdU%Q!,o9HAƘ(:O T0.CةBlgTL?^>˻#%JGƀ4)dUR (bYr7*D~iS`=th?4 Lb7FX`¦ض琕w[ G~bN4Ni9I@"ϞO ̼^{~P4,Qft2-ȾW}>C ͎;N9-8tI;Ks&Z!uN.fW{@~J~ku.xiLa_T!C&MT u}D1O"mbVF;lD|N^rCp"WDy`}±?D|T" h3xm eB+9cɌ)1vq"X˰WxtZm5)vEg׭)K;3#[ͦLa$LsaRwN#7ߎԀ" Z<⣴PGcԳT[̊4iwOf)u9T5\uJ_PXd6m?FLtp HvM30q9T'MsDL纵xJ:/g#2k (zsbŸ$GzPWi}0cL_Yj NPP?_O .- Wz{󰩄J"OO4s"9hMs ;I[}n3 tdə>xkr[SFޝLL퐛h⿒8q$3y@? hTBմ=…-5 RQSeИi 0CFvTR}7JJi~ߝuOre [xXAg>hO Lx'w[1xR%g lWٓB)%+c/wcVȚ  Es܋@ġ&XUzI@!Z\ψ27,#w`gl?.6(;T{j;+A@[agei,;Xg-$ᴞ1$|׎]8EQ O&eboN|زU9wiy hwE_; <5:^y JDG>#?a7Ч`{S<]5++TfDW󮕑WKsXŚMHH::6ϕ1@`)  14r: X] cV9ىC,}4yY7$0Irp2+D }fP6ךb#! tkyP:>r=1FA=j@IJCSuf2x3Ϧ_T$d'x +1ٍ*$6P]UA̔ %霅\Mڟ!r<ڔ,GW -ϝ3eLBp19خ^| ?0i Ǟtgl ]iL/\aU (= m^bEm=. RRo CvSt;9v`{*՞B/C}g2#ݹkT8N܄'Y0Rlyچ;9u?}p-#nk,Dmw*F?C=Cͩo?os .b=7AးLF+yMz'\)0PG^~+}wL߇R= ($GY e 2-ޏew8/`)9vأWy P^'8]:8'Fb?=9aW7lce+]w**;ya> o[rY2l>q3RWW]j>.Rbhi(k|(?,EsS@z:1@¯<{NXP mT( {pDgazX*RYB}$:T@SzM"ǒB=[Oє'd, 0nRva|rT-i6"j5Gl"_q9RPxtZ/sd'if ([$:\)W]tl U[f4,%en2N u4$|s!":K/B̷rnT8K'j?{K@ !7\N庇$hlc)X(+:|`š3 4h+y!X8a ^L> Pwm&kgCOUO$ 7Ɛ9m6SX$ ]FpmĻ}, e*i"y0_gN=nOP'Iz.cjvI;|`4q4.^ ?%i1ܐyV̦ h^QP#_;h]P!p;&K՞\pF y p?:+hF=}]>0<tKQ|rЦ,XxI  ؠv{ e݋FO=L+19Ks4fʐ+`q)1N ;,:e|\E}" !=O:Ӆ#*'Dh =;W\nItG;%l7`ar9]7pUXЩkIg}fezmQ3xL5F FC ,Gz=?i4Z&Su3:Aگ"P()DA.)kjZE]b-ucŘ=-3t'pPx96i<3o8SM>oyϕFLHa2{J]_փ^yvWXuP$+ArKtXH׻ 7 lq9bwmhTax:ER/ EoSvOQ(MUO{ etL-3Z*yO(QLs0 QqF "h(?vGhҬ,<^:dKP5gk̓fo^q` KShk0ݒ?գ8NofO!rH4ǥ}onѕ\dK*K%'_fhpT ]o@#1X/X~YTi[ͯiPi /v[Ӫ7)1kC(/]w:<|&zIsj#ۧ6ȉ~v9a`C = ~/iЙ?6Rw9/tW܋/4 -A~2(';Er}7,nl4wϩqƛܩ &=Μ5A:czfD0Uv!i\x +C*/..8l*p ^ uBh9⻐%ioLM\:HN#&-M̶Pش?6 46OW yE}Y4:=4SV ZLxg-|sx- +e{UFU†+F#VnN1ކtzK[UTA;`ɥ]jH#QXdk\ HXu8{%#md 8x=5[t=ŊGB@=Z01?#H O~0_y ]4s(E~tv]IIJ(L9y!WF l&Y%;)0ݒRVB:m<,}^&)>ȑ:bM@VuQ[b#1eT(5zL:+Hb3 nYi lk#ȗu.XF:xÛ{C~d#p=ۇPny$Cj8~_[v|bn,NZCXE)4Ljܔ'PYœZΟ}]@thp-a5Z$L`{tRt&=Q~?3r6}}t_`]{To6@Oy`Z+ t|])IiKQ]Бe_|U~$T Nu%tu]L%.:TN5FxozRZ9"=NP MЧ|m` MFVq\Uk60*@P(x\ Y=Uت@`C&R):R3KOU!<$.09sÇ~S Pv|_.wږt22m*@Q,z*@# 4#H|H k8dšy;J@}b=-4U}o[mn{:m?DR8əFT =q@5o婧%O+jⵇR %9#rK72vJj_Kbз$F荌ׁ#PA+w]Q #5om9 .ygHWne hu(|Mz@Mr|v0r榾#ℤ-0NEƒ-tsR8v˜Sk2F' q4:7+ĸ:Nd:\Gj%jb-O5XyPuPɢ4t{O.]~uW؂$G[N*ʉ-F@Qg9E[klĔc%!P cBPoo+w|ҹzl^ܳ5hqpl''u{8)Y[޶nOC~:ڨ3&j;bh0'/:l'ū-Gt;EAdԯJ:Ӎ궥z@BYOZ '*ȡmאhGg" (25M5-˖H7K$aR|ÂR8I7Cng 0ȑoWDs`uh髺݈nǰk[@Se^/\ނ l4"^B? }\Js|=݆;֑6i@P!Zsz`kn&T6rFy&jwl0D ԉcYŶK<vӀ{mM/%h9dd'Xɪ>Ȋ#6~635~osjKZT$eD WqH΂cu!O̖ R֓l=鵳3euf ٍucsL2'er˙X. /lP_ ϕ|{U9qXE[ ШQ@Gݴ^hӃc!!ȳ/h&jctPD1j/qcdE_!PyX{(Vx(b#6]AT7UOmPDGjL+gx e -f kcMsu5Tx-&z9FWW,b|"YM T>Ol /w*Ȋ/-!m?FVr.%拨P@׎ mxQq5mz@Y5BҢ+S;VW7E!`JK<1N|Eo5^(]1MW]@kبVaƗeQ(ރc .M(C%j}N zaT!RG4$𭉫h  8%|U^ըHmޘUw)WmMc@Q> ^M@cP (Cy:vXqސ^k@Qxx`S5b4ΨM[2͆* BWK99G.n<ƺQfs`M\Ƣ6ZH*V:i-ywcSiy:"fϼ?m䝉>KNဣy =Ba?YpՃ lm9$56 񑭎=,K^ΡQ@T g ߮3$B} OQ!K?7 6JXKМBr`O /*W13v~{^s@b2Uηd*F ):%,<8b5M<>4+L"ܪ=F(SV9g2NO;rHℇxſ%ٲ5G^9?qB%?MѨ{X6'}K,Z in(I .I\ط/6y5f\ O'L Z'}<rF]Tz)pF<;{kj43f$w(LHE+*Wfͥy84{™Q6ӝW}1rQAEbM)\͇Қ( ~3jy m?Q(CzqxTpIvU01oP.|M@@ *sQɈ Aᭆد 0i 02]49.y o0_B$JZUG]ˆc 1l2mi޴tj[Mҭ{'D3<mUmLt&[`־i 9ل0ɩU7X F@Mc$VWTli3Xi8 ͸@h(j4U4 4·I8S1ݰL|R]|N ML?`q,!9"e?T~RJHeRʘ`dqZ?܇$M C)gᒎ _^~^A'S^ Y SL[r^6آ"$ 4on-oy‰_PDE>c0R[c@-RoЀO/ ]:g-L5Y'~7'+RR/Y&" ~n&YV%Bnd6sD f`5PZ}v[y5Q8qi"hDp^[rXO*E'1Z-j Ԅ 0RoԌyr L*.W藯\ *+o$:1ao"tUw%Fw<@K 'υ&N{y=y#3EaJST4Ǐ1zGBu|tT~*<0b+|A g(>|`a2eJxݮΚ csp;N";Rm"Ƒ}]@'gS AUT]]OEd9SnE+ߥ}R@ HRȅ?>Bϼ|]F֣P`̣,|i2ƾ-cʔFurֶg]@3hyi6ތ{Ғ?PO}uYw/fĖ|U`[A@&—RqA4eP븣 n]m-da9W˦Cdi]l a:1TЬ sP `}c@z!u!5u-Gv󆢎_p9q ZrpYUX.s?< )|W>PÇug<~-Z# NBЃ١UlOs)~#Vs0G\|~OG)qxJG#^_`eHSE|]ME_<[D9)ГDWJL/LyYc{d˸7D*?I% hS 7Ep oXw+ љq ¶>1N}@(KY B<5EiM~z(A@; ]ϩ&P}n˂ w0 .V50j&d=,EzS^=Tsd_KU :YuZBCtp^7,Oq\m٦A7$|dQ¸],ITEquVWs2m%#4_,38?& =V?$vi@X:u{fe&P'eJ{c/(]'A<[ M&P+tCq7ǃKD{n8:*@UeULyCMN@ʏnn1t1@t cnPv꡵ HN @hyO/@5/@Tc4Y4 UFIENDB`_$$If!vh55z #v#vz :V 6,534 [Dd#PV  S 2A05100108b''cWGX "4n''cWGX "PNG  IHDRWdRPLTE  $$$%%%((())),,,...///000333444555777888:::<<Hr"22@ Bn<$USG:E-m99@m9j;X=Z=Owr`r`j B?y>[? C{{`M0E2H&*B jJVąWFGΛɧYFj5җ1TLYt.Հ+HTj 85wLFrxB}&IxuS”Qųl 2Z h "W{Z\lR\QƷ]%ŕygM麗+ҩx,ع$\W.QDV[WE5̩ʫ,vT]pXdndHQ~5\]iH)jx\*F(2ʏ^k EШ qEVl \W u,{R+}I)T^eIyrPE+Ž^i{*quD&.cW+B[iZ .<E6"@1з+ȫ"RxjWm" "ňBZm%?{bEc|WËEՎBċ(I+rRz"sw/WHWF"dQ/`Чg: (4k!j<樂s*˫bȦP@$R,_Iu)u)Zb~x5-AW -*ԇF`9>)JG`,ƣDŽ/ )*J^ej7V`|Պp%#M{]=g8!.y\\[2*j"V\lxK1oPofZC"%oP_v$UO֜ %JP wBMB}bվfjyk}9V:AiZU4V+ZTT0\2qeR< Q9h sN0cjF18Pʡ?nPSĕW #Oc3i 2vauY @1"Ah/D`b7!E#'%'˂Քvj#+' qގ(ITY݌sH?,)*AQ35Y( qD=W2[Ӭr!ݾ/\(ozECۚcO.d~OE<6Msi'$0 W44> d ,Ek=]Mz5WJ2t߳<‚vr2b`i% ?[U{5E+{b$A^Zh)#/S;9̀e+X#npOӰ)|88J(*M T+X7rqe5Azy*O CTfJWmE* jZZ}1")1jY܉ݽ{G0&BhF7]fe=Bq\)&8.Ѕk;V 4M2F)eNW9u~9@_D`Uؕ2h%յ]o3EQ 1V_H4x^ C?lŽgdMy酬;B-d-kgF~o+ٓlMz(OӺ:9q Mޟ%S2ج]?PyYx‘rDTF/Hp,1?lulڳp*vRhcmiMӗ"]P/? ؑDؼE+=s Y2s<[%lc 2ʄ) .Wh1$$Fh͹=}dm E^4Q,šgljh <" qEΜW=A'._¾)[Y6U^[Z;EUGQ7bdnmʾ+UET4u}og ]D~*#o!)t`d ݉JWzI^}~d~Lԋ͵7?(W`VпB <+;ƃO_۸V?FɭjV&tb'ǰ<_d"HzI g$Ὑr-)8<{XhJw'-*U`Y\dhtQи6â'4J^뱋.ƃ㖩iQܞEV4_EBIGÐfϣ˪ܐ 9NqE$Jza3hMyGQtiJJ]NlL#7 ,u|n:/F'Do뇒Y,s 'HZ>li_Ƒp( !?@^|O_:|<<|?>}"/_B1]{2Y=BSŋh_乷o߽=oc e>k?3_ L+>,%LY s p0hg4%QUYKdƒDQ%HɊX,ISc Q $ˊ E݉V; %=sFTG(CTF qg-^M\j&W+^bSRGG~:#;Aq\m!QJH AJ`&+~ qս;{N#pᩂ?lD |jv q!&QvG'Ӧz 6vtԜ2=<js?/\˥/-!>\IzKl5;gzcK8FiNn1^Za-D 8+D&vG:yvt HކF‘"8'4FѸ_]VQZWNALfcA$uLDV]SGt,Ѩ$+e\gE7oKc=+\U,<pW (w\a+bԢ<pFS|JX r.U((l%$QHOI.k=UڃhޏR/D 1Y)[DUZI!E\B!*sx3=N"q@ʁ6Me<֯Ƹ{&lC#6(S A Z-SL^Ϳ3?ʅu7645Wk>mm~vo@T"y5N]Zd2|7mƢ_&J+֊h!B$Z~8#_$޹BP1d'8jYv[(끋o'n\ ҈+ V\z_MF4zېZuKhaS' 15(@JQ p5u˂}HOWq9>'x(DNn)Q~g1lbn8^V0)6ZnI># ⪫9gqUdj ˇHFV ~#\xڕjMI8I0Җc?ryl^äDaO,2b p"䍹" kW1=,{uW%Djv2`UR[\52@Q^A.pb*qЬlj\l¾2JwEU-~E\҈UGg\eye(y0f璘+Jn#,=;Ѯ@^UΫ+)+Wsͫ(adB(URWJEWz+䯈ǫiOCi0%dbyQ[5[7~§^Pl֢;%ڍ+" M pu$=*( h=a:y%}LQ%{rWj苅]Zd>Vk!͜V_HѦt[v'JUQk*[J3+ ӄ|4uE+.#V zX^?~iQz.3b%UWĕN #}\,z:U^w=?4"`+8 /xCL>|4ґ&O dଌx%5˄:mPh*}Mǡw)!ܹuFF~qnL0{ L7G@%!r/h1 jxqw1RjVޙEm=ʱ47;ZՓT=L7~wD.D&ʄ3cK闟mPƕ^U _$\Î8ӛ c8:%A6ptD(o!G6Jp~)_E|Nb;/nm4:pLf,t c0Ƣ,3\}$G3!gpB( n^Rh95t$1?A5#5}Ա8.Wc*k7bFXm`l\O%0%[2G0':FȒC~ ]3LW>FM@={CߐI,N v1SW9HI!)VyuWD0@J/zŔ^C+*FfIeO}3#3Qܣ%iWUuQj р+n@K<%E:C8;K=@Ifmd15 PMiRC4ǼW9C.ݤ(/!0&9-Rw$r5Hh th bdX#fWʂTsʌq9PСk^/H!9݃}lB5fLu u6aÙ>hwW!K$9ˁRki >i@œ]0eHG0L,[H`U5\ #Z!_{xq=p6HǗ᪥5n?ڱ ,=Qcûv,0өDP2|4fpu`؀L2E[ZOoa\`% {4#jXzUIt4ݯ=$ P U|0e&Smp ޏoLJ}2NNG:B5G,*P%MT:iN(ElO`E\xeʋ 3F-1UPQVq_ϡ$݄O Ğ$ p ^AýDB,EXN.chh@av2ov2&0ڞ>dT> $Hāƀ˹R:6KP* !pQtp}09 /m{^bِCTl->R6l\W:PpM篮 x0uFn!kVch@g;e*M $ 㪈$cĶ~*xKHr2/Jհi S0b/& (Me5e""%S6NHY\vPM=Boo.y(^W|~Zax :=U ǟq#{)<;!|`f pAk٭,'{/_s5E>;R[4|v K+<_[<0+@8dSΪʁ`S =U_W3QIaGTN;yőQꂼWG0ڢWsidRj^+a֖|Ds/=9@NWl=2IW9x4Fc WOUt:sgBݙuVjWskc6#h(z[#O"Q ۭVWQowOM>$~Uk\M,5 ag}UUa_56+5}l6 FiwPrZ_6 W{#joZkǿ$'ŗ1Nq0A3l_Ř&2kT]ds4Ԙ|3L7 &27~ä3)p6 zj nL^o8NnhA[0d+X6x#7ތj6+BȜap9].~nQjCO=j2YWCxdn/:JgYSj^=Itֈ5 l8+g`Яq}3~ ⢓}3pi@;Jwd1L>\uoОju͚?}GŁ2mh2g.A7tzh4vaB4g#S%k9q OVxq«5t7!<'w2a૝:2-v'ҏ!_f:j|hxM7m&Ug(#H9q=Yบ >R1ʒܚʸǏiimu@)6L'_2|fS:}LT*}&i(d_|9Jehy8,>r2ap|\*ߕbojZI'@4 bg `'!?Ԙkizl~n֛B]aw,|:Go(ξ肉br]}n&.ۧn9 s`_UvͶb0;o[+ˁ-ll+ s`_UvͶb0;o[+ˁ-ll+ s`_UqU L'0+m,GLW[T*+ɝ73G]]Mr*3oRVl*{OM_t5ժ9W㬱}IRp3•|8WНOIp _ۋ.Kaɞ) zuIN,Nu1lrq{o{&']kǨ|rJ;WL\`2qӍXR߶ln8E3S с?3 >rRLMİ霤Wn:p^nH>dl{YOY(lt;oQG}zgA&>dK=T}'Ѿف4~!p+t }vNߡԝw荼{ 훷Fo\їwJܕ#yN \9U{?=CHY!wk?߽Ȼo*ZwuPTWwTƣ7~9 ]lwj\%)!a#8 Ha=>&2FVr'i8icZa8EO%#LFI*"ds|G= q'žnWV,0Q(c8A8LGֈ]ipDL_eq'] zM5P.؞ 8> 5ZϕA9y9VbyLW"ܤe*W uA pXk!,Mo1t2!GsJPW8 ֡d8Hѣ&h200‡쥗 8-uʮQwYWoЮ% [6vʢVa KR6T*q%: cXW0|"Tuu}QShWn'kE a7FU>+P1ɧW }+t`8  {  8Q_ێit`-.QY .v;n }7-]9}Աox7$k_qFRFGH5nb:W`h"Ɣ\QG sn,2d0hV [4IVmE2!RYR+je،mW#ʇ*  .U^>,8c<:;XąW,mX̟@ٷcnj\<+ ͆ѭyRFOVݴe MT1ae{(0PFPtV9rL,*I6ބʆy67]^jaյxwCum.d©rDTM~ ÑE zXc``2[6WqHV7J5AJݞSzvBbGbrK(. Wi3y~vhң"Ҽ.$\= j90:mXenˁ_[\ݴ/Ɓ-~VWM?Қ=x?Ϸ-^?Z?O8՟[\'ymρ-qvo9zlqznW19yچlG˖⊔Sr[sWܖrOWضj\OWضj\OWضj\OWضj\OWضj\OWضPՠZ-*_[գGYa*Jgra*dSԋL:gc 3E 6,Hċh|O\7oοF^sVb|= 9um;V43>]#Odq8]nr<[.ڝvFӶ]xY-mYth+} >ۭfzaمPrDu;+㊧S;;u _Glio .=vod ;-7v=f^}z^<| z>Oӧ3w?a'p|;,Ka2~*n|w=]SLVWUvtS|!R]~NfF7 =5:{&i^D(|u lXϞ=QQ%Hzh5P8wb밺< }n|o/M ݈G*0~7Fc&cC,:jZ*+e\)rߕJT(q\\1_s-HW U\GZ S-Qzkk K2旙3lau)hXa4!(+*f1?~5F:on? jMVK䛘 -7VUTՄlni8mY(KZ}+)S"T3AߤZeU˲di6ͱT0%Q`q\0`"?<`0g̛|./En>p5y:"{bp+ tU"k>4F:\ʼn8(^rB}PsU+l|]}\eu&(Oz%=Ž^8oUGϊ*ȫN ]dړ$2߈i0שWD$HnE\HNcdÐj *07R*D7#,V^uO>vD ,ѽH W= 2tډ6+ EE$\l /s5eSU Qo0˿RFԔDV[H".Ad2:]M=\7@سZ2i\<=p0nHpۨWi00(B\dW+WZa}\BHt?BY+뽵'ʍa{ ,PѲ 0 ^@xC#W,T";:5w >DvF]@pBG^{xSS#3Í]: Ӎ.< 6hPACTwJeKuC2e\U)J^n+C$0?.Сݖ潿W2<0QFa36P60XAWxJZnH [a 9ĿRPak%.?zT9\ mc=e4}GD^q4Zlg;xnTUg-Id~ڦ 3%VkǦUG=rxcP0o":NqSOX]eSEۆrHh5]cy5$wW\ J/z;m5-Fd5Ca2]Pz AJVcb*̛n܃ }+vZxʘ(5p(|MOI,[ēj5BFØi@TԂ>v1u8,~+*Z7bnZi¥Uv2 I!IS`&4}ԶRwNyCnP`R![CRb'U6½6S 4 "!7_9]Yh("aoM+ byw"yXL\8vRagq(B NDOMtAaZLQghXڞ@?}^1D~P ςrZ12>(T^}{_|CqILk͸vW{;YFYZ{r|x /_}6nQ?M%uuL~wVF[ie\ Z0l2'QG &9=DT?&trocq'17O (Om[y̺׷S{WZ± ~+ssd.?㘝<~ (D=t:W=uAy܆7mԇ.2QZ Iu-BNݐbdMVW%ܚq5%pܥH[I>wtt+e=*MGX8lVxNշҧzz2[iNÍv y"(oW;Ovoݴޒq tک_-T%`!_(75 E|7y/J;?PwwN4{˗/3sk߫7g|'z. σ]b=|P?j 'fy)T ȭF`4-DZAsZe"f1(a;0PQ0 u@ѧ1g3JLCCayڠ*3PSA8K–Z`Ζ_6ha2!ur Zp5`zF9",`Y@G:jTTeXF Ntւvog?R@z@#!Yd#r y/W-KؑGtǿ~\ʇ!MN9^~-a+kme",qF.$#E; 9V7}F?$[\|d !y궎dҧ:%I˹1%rua5:njcf"iIp@zގo3oO+6\Gi4.בqC95hUk0x'; 8X.P3z"6ؗQ8 ~, p1)3#t+ Y{y/D|D+6\Iy R`áGԅq$Bc)K,֗ X&H ,}Z|K(nC ~ p H{0j5U4"3΃Otkg=ϝi而94HJň/M̴}A^Ra9W>x :`M\tJ%)5w DR?+e\<,qS0l(-6s4,bQ_#ײ2uT=-H1<2'qӸJ,7 hE) Ұ,/$P P`L /k-AZjfW}s4]qܮX+[ uO:q@^iD#e=@XPhtecVp 7@[x: /ҎrLiU,mj%ߤ@=[JpyE ms)ޔ%!)㕨N)p~L*.K݌ &E8CL^e?֘ԭWTt5BU3pm7 aʍbJuZŝ0)&yL4\O#!\j>3|.  ě$WZ39Fvr'O?(%Y3.wKz??Aey .ba?߅Vx^1~5)_<. 7 Mi=AHƇjDT6o@ /*(!ƿ{~E] ='`0\ tgAoDڑX\ ~1ƗJ9QC|-4'/:PuM8)JY]'}糢,{٢]<@4V x8}?pqͼ9] G&7sjϯcA7 TB@\INlNpSvܙ"'E\1)[B$XlgzQ_4@T7u8 wq 쫹~ap?%f!q|\:BPާv}/W rR˕J#Wu}/n44\S3ɯ7~_QImc Z[q/ue\^<;j1s(5eaP8/ Y%gu™dv^j9v{OeB{{^0(Su4h$rpXt gZڙ2xU1cq}=L^aa }nd{IqB_p+}f|=n2׋"VGk9&ԶJH\x>]g?@ಫ[pͶflN׻߮b3);`aa.X3&MTٓ“eMAh^y}O+r\0Ygs%. γ8\ft60@+[V; VfN~gz~vosBX!p??f:E0DYUr@GeM3z99VT)@@Vfc9aV+LCn$s-b@||U%:%^5p l6U:Ya 'q-,C˗/wdӗ'}b~o^k7u5 H׋?EFJsCVt f!6ӧ{6 HM!7Nwʕ]6IgBYp׭QwA<]t*t?}oGWްO  ?pn|ϫ2l.6\kP"q5h jxv2|n0%KDzֳ_jj(Z]QpIQG{ɉW[.MөL:J_›Pey2vE& {߃9l'ĸ8 +*3K$A wJ2?{ETn+PV}h!lwqRpzzқIU` XOa=GR$1L8 q柙Fy4}!15HpEKXq-լF_snH !iyB"[,J9Z$I;<μJC ۠?1 'nR8x$T2$O 4RG $f±'0#ad@@!nyNuS>czssƑx /|&"a^LL yH.TLʼYR\@)x"U r`Y}=qp5X"0*csY )9%Xҟ9 ~39=POOdz!67 ,sp%`wzq]6  *ăAD؇jZ+`Ńzd B}Ϟȑ +DHˬxKQQRjD.I6fSL&ua,bx9Rۑq'``{={_pEyf |c@Ynt=\?'_kɼ~IH+,F1@7W*| -r>_u3@`!,Iڡ 0u\ܔKP,0uW*^IK6me W"B+< Y4'HqJ (w8@.2G/Je2/aHlT"zmn;&Dy'bl",'KP"5E͑c=YIdحWVxUQjϐ;QEb|W [2 ]{⦀}E+/ l6ZvEh `dDLB*QFJ<ˍ9Vvkng:߂8_~eT/׻Y+e PT~ Ahp+˽Bxj'Щ;U{纐sI7(&٭" y̎E D#0UDCZl`(bAծ-uoE+qVUL>u&t.s運 Ad=NH߳j K|OǢsk;k0[}\$b>8;bFru)54HM~9t5a{~yC1G*N0&s+y5N`9(.RUX'n]t8靣^eUNu2}.y͡ ̄oW"{ }% iV[̰ONNyE:dye;ײvˇ,hW]:4OḞHo(|Q^^+Tf`ԟcPmL{0dyzk-.21@.y!wa0g>.$Kzm IAu>>j C}=s{Mq;PgD}΍Ce% le9IJ5"CPx;zhxuSgFё0fP<'\rcꢮo&.^ qG8>[ 0m9o*@AD ܍)Y|&l6&17L+\LYy3m6|3 zҹyn1os&fW} AG|9 `GH <sx 7#\?{6Iխ:#g[+C>Cɫ%FS4 !ZmH#S\YsǸUK"-xLjl9ԓK}A.dX@QߞTv'0+8B݌98u&p;@RD+qW`|tw d9"DRDn+mυ~Vj6{=M.ɌgjҍЩuZ mȮq ۞|4%/dqIJVU7:7(u6Afrb\o 3nзLDD +^SemJPczcEd永OC! $;6| my^p_aS'ȫ6L{>~P ?c5(;LNJp儬$5`+ &czf >;i`P/c Nƒ`<0'`ބTUW4[D}L "NTB;[CuLWP؟DB e!/],E(]OA)së(P}W@>k<=-(C@QoqΡ;F]MNHR\Y^V`H8KNK(!5Et rfW-#uc[Z quaȲ)ؒ,١TQ6/r|,x LbnL1.1i$i0i`Yۨ*.G{fV&A9)}Es!&>SF)M4D]H=Ozt5r @,6 Lp<= ٻ(xIJ\5 ̙yUy  )D%"~,#ǿ ay /aPYu\پJB1 6WSii?m*,D9cW5TyNDsxqNHc;0c Pk(j; XN=K9{U@k)t|(gPOB!Nk 8O5Vp,M$by1+H#"^;BqTx*oVʚ-z끨W `L=2C/pzwFDYTépQ]d~PQoRA,}߇Pg,T DmvQ lJ@b9Bk{9')m۹z;WỂ`~R+v²HIe?‚sSn.5P|9D#2נ\ jV6ֽb/">(yԂx/H, f,v~Iȟa0%ZМ7Up}!ނ9K/z~}cwk:側)bd^Yywqo?k\17دw}޾-{!9(tm4/uXw7^7p_RqƩl?h&VϯC[a`"4un[>hqE G/ WD'"(XEޟ~vdJ>]J[NdYI@^Cs4q"_^L֊W99/_[{5Ё?p|"ʅ.w "=p W1p>*KgTx+z *ɇB}$ls-f2Hz5&FHξequlϑWЯoBɻ/ 5js~%pªT=]_07/鷰هB^P{DuIϖW*puerN;E\֝ԑY W+}?ϟ?OG XP;|z1it\c珟k|?ǿ>>>?ǏZ翾|ra?6YP燇߼ɿ}^p흛߿yS޼}_g#bߝ~x߾۷.}x#z6q4gx_IE= 0|Dψ_ϟo3æV`>P_>q>x}O|*q 7-SA<駾ؙqOZ sa1J'Z--(_-Yo|0Fކq _o4ZYk>7[B xl֨[ύDl'Op bk!-9WZc $}mӗ2YLj \yurv:ݸ[w(NgD3.=TAeA?~{Up`A&ĄJFglh4ʄ#7pL>|ߌIu.|֧*pj5,8&sݘ7Y7IgDvv~ᅰ1cr fzèQw`2Ez-k Gq6%z,;/4>MH2%3׸L2LҹWGL:2\#_RٔJݷ}y/s,K8rx,C)EI6 _drGnWw _WRXy_)W|sJT.幂_> b{N3(}?ȕ2_PQ!p^5N;ʲ;E8O}i(S ܾXw(\Xmse9F\mͅsom90*7[,ŁWRM^8[j+6>7^>|X۫X~\8Lm]l}7uM:OW[ۚ8;ꏓW{9;j+0*;q{;ા]쏫?Ӷ epUe\ΘaE-wG]nV%= c24\sl4xPm/8pRFzſw\t__7DEpE[G>tFSqVo@]g݇5zQFHSP5v-ƶPmƐ3`©jT jp%b?[[yEź9k UZ Yc Q%MW G :|Gތq%CEYo-=UnAU4|өMU(BiK4}(aD) 3XgFj婯QWqv"y0>2A`_yB(e}M iҤ}n׺ڇc"B5EQzpMF<;11vWV@E|`[y)я+WmWTWa)*BR5UU+ 1JAM=|_|/4ٳOd?տ:dYūy}?/_^5agP!x|u󗇯^Vfkx;|w@j x,5~;I߿;~{[.p+)|OWO_WM1~{"Ϊ:TimunLd$᜵kVn?+ELD5QQhԴ \_Sà˾+!Z2pũgsk#) ^@ŞO0EY5.Ьr^(eѯUt6油L&Lg&+ Gli% Wd KTKZyU$úqWd=xC~J"9 *yj WdU`jcd˷Up W$2Qƅgjj@B\ö lq5[\b UR,40u"|PNW'4=:)"6Q+}FMGz`kߏP ?`R YK61+%FX*HVf/Va<4C,--Apd @c@}N}fXuОuZ<P[dxz!તt,'cbG3#ɥO$@WmCb*ntW#BzegCuvkhEY^QpDxs&zI FeҵʹCGU;^J++9.mSFptJWIu$c7Ƹk#k3%Yzآ qTcn"E)@;-F |hf y \ |>n&]yTLO!1)7}l2Oe!gh{^W)Zsz*>80u+ŀ+E?(put䓆ϻ1cHv:\J~U툍uzhO3mϻ*0,)B |J[-| 댓BdCU89@]8Av_ 8M5W|H}y?`F b&~fqÆhc51ʕZ"5`Uޕ: *DAd$W#OywF͎iK`/K_x +bqۭ(kM$⡞{)}E+rgP}km8\7"I=#Ƕ%aJV>\R W=;8L +4 V_JUB}x@nߢ0S5R=0du8m k{klT@ 8XX 4L^΀|JZL.K \6iK,68X6 l" 1w/Dni9*A T=O{BѮ[gçDC.@8ȫ: X F{gQao?RT '7T6XJR#PhF^y#c5q# _$*Rc*u" d04D|) Q.v=ZW˯<}ѥEVxӛױ"|-x^cϫ2\}^) ;gF$Ⱥ/էWK=g\:ܽ{cHzc6=܇GG|\wd$` S|q~ެV!U,E ֌~.bYZQ8, ef($rim0^{B>c7זe{bG o}Ѱ1MkX}4v!l`9LXEII܊*p`G'W 2$t+{P9L{)W28am/Pѫ{vU$Lł/k* gOky_f=~R*^˫:nxPqqj1P" O~.D6-I{kpbS.qY,\5@`\+zgrX| F|O‚jp4CKSNX 7a\$m WWEB?l<,?8x! wP$\]FN^\&(6XYܪ K29Dp%˫2y1]z)53)~rP# J ox)Uu$SY׭RE`X @; Zț%ji!FH՛EJi|0|kx\j!)P)\%)jeJ@#XWLg û) +s(X`UfBݔuFDF?uC韎U &h6ǔssi -_!*2yU&ײ0$#KlH-ɝ-#NMA \MƍP7]Aj'7`QzA6T^) :,XdB1v)Þ)WH^Xxt' =)x]vŕ:u>(t`">r#k+߁1@ly+)t(D}08*q+NkeJ@̾g{=(`g975Qe:j)*5jS5.B:[-7(MTI"9R_ܔ a5-ː@CD +Hc.h\*5tPՌ7#'pK f$twU`JAE4.u[.dM/kA^ډGQT` (sQI@R di%lXCD#:οX\]wW?q%G/ VkC1w`[3M;W^iZEl% ! 8Yea&D-`|]_m*YEy+sԒ=d_w> 3=Ly363q!0=>KĒ Y Y炥|./ 9O)|g{ k|trw] 桮M%ի$˻A>jZ}(G^G+{nWV} ){UOǾqDQ%X6ʲB9Yެ2yTT"^z`(6aT( R ү(ȈUY$3•(lq5C^it__g1WG~-`p"SW!uvJx!WJ$R?ͫ!o շkem5T츦I?~e7aCL`/ل:"yz]`~3؇y:3VܔwE8Ů\`-Rfv]W(V(}oG $< !O!2\iqm TNS}Љh^~QFYI3L0@LU6v U3i `EI&\||$f-#%dNU+[ WA@^UQM Í6}̢S0ԇT"^3uf,b(7=972Y&ڬ~qz+е)A嫺W~A^NNݠVgu,=EaO Cs(bB~B%_x ^D:*k x8!CeP^Y.ΞP}ٳ ۇmM)E32Dxb5E1J>*5RvoCC#q΍Q%JJD4^R4P&?C8.•=`Ԇ, jCQ>.&%YخY^/Q<=R>0(/bggg<%˫C@v.,x.膐8: _ #[5QÈϋ jhh>B'V.׳zT6c3ۺճf(eZ+_ʢ?wS鍚DMsllgQ#6R0˫j&+2^ n;UYD:) ni*g!nu[(ڷg"f>ziɻVDwTSF,WI8c/z WDdP_~K^Wo<F u&Q%s|mHVcd}fyc?&_vnB>GswzK#xO}AqfW@}krz~1݃!o v§bl;FU\ W!y~HXu[N NxqORM05&`y٦ Vpˤ}fsaE}1`_Au67Gz rߏb='d V1y#ӌt@8lʋ| g,YlX* I; b•bVQWwYœ߃WԀ|\5 qP!gQ:PQ*{ |t-}Ѽ)pCcH+XS`E۹ *}rJJMJܻ k=ТM8@);iAts|5D(wjhFZ<@]K+z ly(*Hx; 聄Y2&*yp*裐5du? P kΟ*@54mAЭ3?m:֯ Tj;mgK+,:Jϣfm˞qWDhZӁ۰/3޶',Z6^\&cD|(9چq器G!iq@cE-y/R!Si -w*v\!YbiܮY1r;~Qz_Rt*K҇^XQD,F]o>vo7ęyꅞ1SV8aa4[l,rt'0 OIQS$^vX$(c?1ciL87G=bC f lZan\ɑ#W/_O7-ESPG><!fB#>_BYDw7wdW%~܆Szti#C[Cy0‘O  dKJ˼W^L@ޅTwQGZVzc䜮d![L|B'ò?b\0׺IX^bp%b,jMP5&!cSQJd#ȴhKxq WZ2\iW}Z&yR9rTMAX_i\Ҍ+,x/ =q׏+\f&\IjIRٱ \mt원J(J\co aBs7Yk'qΠUj=ämWܕ: 49m(g#UjSI#~2dҚ?pAu佳0/'mֹk*>l9EhopUkk=PwoLM?U1o p5[Dg:4vhH!衚f泷FZsUB*j0G!D#+faB5HVcg_c/ '&'Mt-=o,ulS. t]5׋ϙ I35:z.f4G\T5xVN9xR)$xb! W _8rSçvF20wr%87ykb\ ,9`V#<REv qa5}]}:5TYCaBB,%+vX!O郐T(tmE#Ͼ )r3IV?/y4"wgਸ਼0߃0Vޛ.?RCm*ʲ *Lcp{q[3HVqș&hP1𸤟J6ōB%p:ۯePVZ[B> @Vh%᪎:^Vs{Ce"<5{/ CZNn@L $((8zhm+Cjd* 7zWw! ]OʂAl">'pyEA!l?mxV̘6U|~ʥuY5d\6toX:+u`]U*ͪ2VcP%hU3=ec2M%7UyYx ;=4% @O2^.ޓr'ޤsIZau j?vhvݫ\=?qʫ,3o0è |@Vٟ-!BU3@Ez;jBKM(`0ՒS`f}f1N|zU0}h(9B yUh`6>KP[6T ?._G Z$0b plYwFy?0.2"{īїu}+\/V q+sUDvS*l_Md!xז\=)y~FJEd7H-.f*F0.\k p5W^'v"Whϳ.+N;W>Vٽ:uJ^ %B}¹z Wk%ʫ++zUt=5s]NYؾ[jn3rż67z yCRjÏWp Gz′oC3/f / l@v?%-8xz|~O\6pdaƞD }2xgG 1!1GA爬&ONvyo'v&=Am;~*](o׫m$OaLkwY_CfnI pNywڭ ~ m6g+NIf b6-& m4 XQ\qjlm3 ak'1\:[R\Ʋx7S7D$}bC]dg% _BShzѪ5j<7>vljz j6]/5[ a*߇FΜ]ϯۂ^%U)Mln6af{.Vm lqg󶕛Wi3yr`{?[\mf9f}ڟ?W'Fwn[yE8ꊰ{[?[\!mF9Fٽ}?ĨcIENDB`DdhV  S 2A05100101bSz&GAsaJ/Un'z&GAsaJPNG  IHDRUPLTE?8????PPPPWP_W_`g``h`ohopxpx%tRNS?BObKGDH cmPPJCmp0712Hs{IDATx^]v*Kkynb76Vo$aIimY.HlBԟ aƿ}.o*f0 "zJkq7Rgzy!ޓ8krW߰|6s k/=΂]\t[$YAl~l/Y> \n&̓zQo__h^.LtNU dK+^O6Ao(ʱFMey\q.v% [#V{k> xi~7-mZjq9/kVÍũ>}e_*߯Άۋ+ ccd%7S{UA FB׉!Q_!޴,̶2ZVֵ8]]Xw9!lhUM[ Uky^{}-MZ {#ö28l hқY_ G-L<2dՓU`S!6=NGL;Z;1!YO&xT)dDibƮ:Ύkק@>ząvW>{y@u.[}ȟs9ĭ`on^N{˗^*^Gm*6Wnˇ\`vb̨N(C,zjC.kt[˧!CSGU@zˈ6_qƖ_[y⣐C=KwSpSuJָRє/T0Iz1[IDاy&> ņrtRuq̓="p&CH?t3MEU96$ zg`%fٌ>-G6z8kUJo {T,e\[ۧLM'Hs|u"M>8y*Sh Oi.i'g#`E+;*"CnE>?!1s8P|`J g/EQ[\Ë#ٟn9iO>{ޛa25?T~xSK ;yqIwtsxhyR]-@; %Dd5Y4+(u¾ądTsaw0Tsa_ʧvn<@\{.ٕ"#fH=KTOnΦĈƺ~p>3W b]wiFm`oc}``e6츲{g&,Lٰi'uG x4h|7OtU7mc-rVCk?Vzƫm>/:Xv)]]`J} %֊q{ovKslyE6al+ﯗwp;Cn;E,*{6Ǎ#eX@#-G7Wfdi2y_} heL>4:եjZVtZy3U^`xS=c&QO}XFB~UbK֡gHiQ+ֲZ|K푰ѻk@?`)QFu4ݵzՎbknXRWxqc7M^=[MjYr*%ZFzvde;}<QCOۺU}Ƥլ5}̼Rz;jA -d~5kp<+oh/kzjo C{KCH;,NaX=^yb_WwCQҒC92teώ;܀xI`L{ӮI쁎k<1(=d>Jv Z:L'0;r% aw[쏰}Bn?;q`tڭ谫ޭWv_ؙvR#:#As$nv7:$F0;cN;Ii3abwڻ8z)ÝNRAiw`UMsX{Ҏ:}ўN;&<(ޡ$W*ȚB d خowjujݰqނJ}B˲SH 6؛ ; &\q-@Ϟfw0:1]VW@q[x6WGs,]'!"ULUx0BHIDtD]U,OU( 6,8@84Ł0ܑET}RWga\%x`< (-9bDCk6LL g~##i..]:x8GI-9b3؄a:;n3O c?:1k$H M ;YB]E#66uX|)o#ϡ̞{*} x~nɪ'3ȢB=O).Y0rcgQ; MͲaϐ{>K\|3}&QO/䔐伬feVs=gF^(9gײSvWI*72>ZrYJ F<Ŧ~!oD%[,degH %y)[1wO_L І!vcSV.+`n=g-$ R 8;:4Rbǫa޹^vf]6-AdX`8ǔbPXјx# SY9CB㤧[1`b,y>K,hleUֿaJWfM|>__nj0IENDB`g$$If!vh55#v#v:V  6,55t34 N@N cke $1$a$$CJKHPJ_HaJmH nHsH tH$A@$ ؞k=W[SOFi@F nfh*ph"W`" GIp5\J  "& "& "& "& "& "& "& "& "& "& "& "& "& "& "%*Y/5;KBJw`jget    Lt0 "p"c###%(5++Y,--v.w. AKBJJr !r : r r Tr !r r  -r i2Br 0r E$r  -r fm`r ō@! 5@!r X8r Tr OQHz Hr /r aZr &<r Tr r @!|X-|X-r "`r r lr Lt0 "p"c###%(5++Y,--v.w. AKBJJ0000000000I00I00I00I0I0@0 I00I00I00I0I0@0 I00I00I00I00I00I00I0I0 @0 @0P@0P@0PI0##v.w. AKBJJK00|dK0, K00dK0, K00dK0, I0I0 `D" |D" D" D" 00b x|8%(*/42: ?zA6DH0KL6Q|Tb\ *-./012345678:;<=>cdeghiDB +9f ,Ls~-10 = ? mo "_#a#%%%-~--JXXCCCCCCCC Ar!D^Br!X\Dr!\]Er!Fr!>r!l*?r! xb??!?"???&@'@AAKBUBB CCCDD EE*ETEZEcEEEEF=HMH{HHHH#I)INIOIJ:::zzz:z::zz:::::z:zz:::::z::z:::::zzz::::::zzz:zz::::zzzzzz::zz::zzzzz:::::::::::::::c##IJJJRs GI"c###--v.w.J@L" KK !"#%&'J@  ,2@BHJLPR~UnknownGz Times New Roman5Symbol3& z Arial;[SOSimSun;ўSOSimHei 1hCC >% >%!-!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[>II3HX)?GI2KThe development of the research of peroxidases in mechanism and application MC SYSTEM MC SYSTEMOh+'0 $4 HT t  LThe development of the research of peroxidases in mechanism and application MC SYSTEMNormal MC SYSTEM1Microsoft Office Word@ @3@@q >՜.+,D՜.+, X`t|  MC SYSTEM%I  8@ _PID_HLINKSA bmailto:xiabl@ustc.edu.cnbmailto:xiabl@ustc.edu.cn  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijlmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdfghijklmnopqrsuvwxyz{}~Root Entry FLjData kw1Tablee;WordDocument2SummaryInformation(tDocumentSummaryInformation8|CompObjm  FMicrosoft Office Word ĵ MSWordDocWord.Document.89q