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| Research Domain： |
Molecular and cellular analysis of the aquaporin water channels |
| Keyword： |
Molecular and cellular analysis of the aquaporin w |
| Research Production： |
Water is the most abundant component of all living organisms, however cells and tissues are remarkably different in their ability to absorb or release water. Water selective channels had long been suspected to provide rapid water permeation of certain tissues, however the molecular identity of these membrane proteins remained unknown until the serendipitous discovery of Aquaporin-1 by young scientists in our lab. Based upon this, efforts of several research laboratories around the world have now defined more than 200 different aquaporins in tissues from mammals, invertebrates, microorganisms, and plants. Current research in our laboratory is devoted to the structural and functional characterization of aquaporins from humans, bacteria, and yeast. For example, we are studying the anion conductance which we recently discovered in an intracellular aquaporin. We are also studying aquaporin gene regulation, and we are searching for disease phenotypes which may result from mutations or perturbation of specific aquaporins--a list which now includes diseases ranging from renal concentration defect, loss of a major blood group antigen, cataracts, renal tubular acidosis, Sjogrens syndrome, and brain edema. Collaborative efforts with laboratories in Denmark and Switzerland are yielding the details of tissue and developmental expression of aquaporins as well as the high resolution structure of several mammalian and microbial aquaporins.
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Promulgator Info |
| Full name: |
hichem |
| Country: |
CN |
| City: |
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| Company Name: |
hichem |
| Homepage: |
http://www.teloon.com |
| E-mail: |
reply |
| Phone: |
86-411-82819585 |
| Fax: |
86-411-82819612 |
| Company Address: |
Renming Road, Dalian city, Lianning pro,china |
| Zip/Postal Code: |
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| Introduction: |
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