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| Research Domain： |
Single Molecule Biophysics |
| Keyword： |
Molecule Biophysics |
| Research Production： |
Having observed orientation-dependent interactions of fluorescently labeled single proteins, precise studies of biological mechanisms are performed. Unfortunately, standard fluorescent labels are often unsuitable for long-time single molecule imaging, especially in living systems. Thus, in order to make single molecule methods moreaccessible, we are developing Au and Ag nanoclusters as a new class of fluorescent labels in biology. These high brightness, robust nanomaterials should enable direct labeling of proteins to image live cells, study protein-protein interactions, and potentially watch individual proteins as they fold to their native conformations. Au and Ag nanoclusters exhibit discrete excitation and emission due to being composed of only a few atoms. Consequently, with size-tunable optical properties and absoprtion comparable to semiconductor quantum dots, but with improved photstability, these nanoclusters offer new opportunities in biological labeling. For, example, the extremely small size will be less invasive, noble metals are not toxic, and their discrete energy levels enable energy transfer experiments to be performed, all with weak mercury lamp illumination on the single molecule level. Much brighter and more robust than organic dye molecules, these advanced inorganic nano-materials are being utilized both as optical memory elements and as photo-activated biological labels. |
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Promulgator Info |
| Full name: |
hichem |
| Country: |
CN |
| City: |
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| Company Name: |
hichem |
| Homepage: |
http://www.teloon.com |
| E-mail: |
reply |
| Phone: |
86-411-82819585 |
| Fax: |
86-411-82819612 |
| Company Address: |
Renming Road, Dalian city, Lianning pro,china |
| Zip/Postal Code: |
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| Introduction: |
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