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| Thesis Name： |
Advances in Dictyostelium discoideum as an expression system |
| Usage： |
social amoeba of slime mould |
| Keyword： |
Dictyostelium discoideum; expression systems; heterologous proteins |
| Remarks： |
Advances in genetic engineering have made possible the production of therapeutics and vaccines in the form of recombinant proteins for the treatment of many ailments like cancer, tumors, hypertension and AIDS. Construction of recombinant strains/cells using genetic technology and production of target proteins through cultivation of recombinant strains/cells have become increasing interested in modern biotechnology, which are widely used in production of heterologous proteins and metabolic engineering. At the current time frequently used expression host systems are prokaryotic bacterial system and eukaryotic yeast, insect, mammalian cells. However, these expression systems have different degrees of limitations for overexpression of eukaryotic genes.
In recent years, the single-celled amoeba of Dictyostelium discoideum(Dd) has emerged as a promising eukaryotic alternative system for the expression of recombinant proteins of high value[1]. In this article the advantages of Dd in comparison to other expression systems and advances in Dd for expression of heterologous proteins are reviewed. |
| Original file： |
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Promulgator Detail |
| Full name: |
hichem |
| Country: |
CN |
| City: |
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| Company Name: |
hichem |
| Homepage: |
http://www.teloon.com |
| E-mail: |
reply |
| Phone: |
86-411-82819585 |
| Fax: |
86-411-82819612 |
| Company Address: |
Renming Road, Dalian city, Lianning pro,china |
| Zip/Postal Code: |
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| Introduction: |
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